屈光参差性弱视与斜视性弱视的电生理研究

发布时间：2019-04-13 12:02

【摘要】：目的分析屈光参差性弱视和斜视性弱视的视觉诱发电位(VEP)与对比敏感度(CS)的特征性变化,并探讨2种弱视不同的致病机制。方法采用德国罗兰公司RETI scan 3.15系统对20例屈光参差性弱视、9例斜视性弱视和18例非弱视性儿童的双眼行VEP和CS检查,进行弱视眼、对侧眼及非弱视眼之间的对比研究。结果与对侧眼或非弱视眼相比,屈光参差性弱视眼在高空间频率条件下潜时延长,而斜视性弱视眼在全空间频率条件下潜时延长。2种弱视眼的振幅在低频时均下降。屈光参差性弱视对侧眼与非弱视眼比较差异无统计学意义(P0.05),而斜视性弱视对侧眼的潜时在低频下较非弱视眼延长,差异有统计学意义(P0.05)。屈光参差性弱视眼和对侧眼的CS与非弱视眼比较差异无统计学意义(P0.05)。斜视性弱视眼表现为全空间频率上的CS下降,差异有统计学意义(P0.05),其对侧眼的CS则优于非弱视眼。结论本研究结果支持斜视性弱视与屈光参差性弱视拥有不同神经机制的观点。斜视性弱视的对侧眼并非"健眼"。VEP与CS检查对弱视诊断具有临床意义。
[Abstract]:Aim to analyze the characteristic changes of visual evoked potential (VEP) and contrast sensitivity (CS) in anisometropic amblyopia and strabismus amblyopia, and to explore the pathogenesis of two kinds of amblyopia. Methods VEP and CS were performed in 20 cases of anisometropic amblyopia, 9 cases of strabismus amblyopia and 18 cases of non amblyopic children by RETI scan 3.15 system of Roland Company of Germany. A comparative study between amblyopia, contralateral eyes and non amblyopic eyes was performed. Results compared with contralateral and non-amblyopic eyes, the latency of anisometropic amblyopia was prolonged at high spatial frequency, while that of strabismic amblyopia was prolonged at full spatial frequency. The amplitudes of both amblyopic eyes decreased at low frequency. There was no significant difference between contralateral and non-amblyopic eyes in anisometropic amblyopia (P0.05), while the latency of contralateral eyes in strabismic amblyopia was longer than that in non-amblyopic eyes at low frequency (P0.05). There was no significant difference in CS between anisometropia amblyopia and contralateral amblyopia compared with non-amblyopia (P0.05). The CS of strabismus amblyopia was lower than that of non-amblyopia (P0.05). The CS of contralateral eyes was better than that of non-amblyopia. Conclusion this study supports the view that strabismus amblyopia and anisometropic amblyopia have different neural mechanisms. The contralateral eyes of strabismic amblyopia are not "healthy eyes". VEP and CS are of clinical significance in the diagnosis of amblyopia.
【作者单位】：大连医科大学附属第二医院眼科;
【分类号】：R777.44

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