鼠神经生长因子治疗单侧突发性聋的疗效分析

发布时间：2019-05-24 09:31

【摘要】：目的观察鼠神经生长因子治疗突发性聋的疗效。方法回顾性分析2013年11月至2015年2月期间诊治的124例单侧突发性聋患者的临床资料,其中,治疗组59例,对照组65例,根据不同的听阈曲线,两组患者又进一步分为低中频下降型、中高频下降型、平坦型、全聋型4个亚组。对照组依据不同听力曲线类型给予相应的常规治疗,治疗组在对照组治疗的基础上,辅予鼠神经生长因子肌肉注射,疗程均为10天,比较两组及各亚组间治疗后的总有效率。结果治疗组总有效率为64.41%(38/59),对照组总有效率为44.62%(29/65),治疗组的总有效率高于对照组(χ~2=4.877,P=0.0320.05)。治疗组低中频下降型、中高频下降型、平坦型、全聋型患者的有效率分别为82.35%、42.1%、72.27%、66.67%,对照组分别为61.11%、28.57%、50%、41.67%,两组间各听力曲线亚组间的疗效差异均无统计学意义(χ~2值分别为1.933、0.803、1.326、1.510,均为P0.05)。治疗过程中两组患者均未出现不良反应。结论鼠神经生长因子治疗突发性聋有较好的临床疗效,且对各型听阈曲线的突发性聋均有效,无不良反应,是一种治疗突发性聋安全有效的药物。
[Abstract]:Objective to observe the efficacy of nerve growth factor in the treatment of sudden deafness. Methods the clinical data of 124 patients with unilateral sudden deafness diagnosed and treated from November 2013 to February 2015 were analyzed retrospectively. among them, 59 patients in the treatment group and 65 patients in the control group were treated according to different hearing threshold curves. The patients in the two groups were further divided into four subgroup: low intermediate frequency descending type, middle and high frequency descending type, flat type and total deaf type. The control group was given the corresponding routine treatment according to different hearing curve types. On the basis of the control group, the treatment group was supplemented with nerve growth factor intramuscular injection for 10 days. The total effective rate after treatment between the two groups and each subgroup was compared. Results the total effective rate was 64.41% (38 卤59) in the treatment group and 44.62% (29 卤65) in the control group. The total effective rate in the treatment group was higher than that in the control group (蠂 ~ 2 鈮，

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