KL-6、ET-1在OSAHS患者中的血清水平及其意义
发布时间：2019-06-07 09:57
【摘要】：目的 通过比较成人重度、轻中度阻塞性睡眠呼吸暂停低通气综合症(Obstructive sleep apnea—hypopnea syndrome，OSAHS)患者及非OSAHS健康对照组研究对象外周血中KL-6、内皮素（ET-1）水平，探讨血管内皮细胞损伤与单纯OSAHS的相关关系及相关程度，并初步了解单纯OSAHS罹患心血管并发症的风险性以及KL-6在OSAHS心血管并发症风险评估方面的作用。 方法 选取2011年3月至10月期间就诊于湖南省人民医院的75例打鼾成人，其中25例来自门诊体检病人，根据Epworth嗜睡量表（ESS）及Berlin睡眠质量评估问卷归入非OSAHS正常对照组，另50例研究对象为该院耳鼻咽喉头颈外科同期住院病人，根据睡眠呼吸监测（polysomnography，PSG）结果归入轻中度OSAHS组、重度OSAHS组，每组各25例病人，所有研究对象均无诊断明确的明显心血管事件及内分泌疾病、肺部疾患、肿瘤、急性期感染；均无烟酒嗜好，近期无重大外伤，无长期服用血管活性药物史。所有非OSAHS组研究对象行问卷调查（ESS及Berlin睡眠质量评估问卷）或OSAHS组病人行PSG监测后当日清晨空腹抽取肘静脉血，专人离心取上层血清，放入-80℃冰箱冻存，待所有标本收集完备后专人采用酶联免疫分析技术（ELISA）一次性批量测定各组患者治疗干预前外周血清KL-6与ET-1水平。分析KL-6与ET-1水平和呼吸紊乱指数（apnea hyponea index,AHI）、夜间最低血氧饱和度(Lowest oxygensaturation,LSaO2)等疾病相关指标的关系。运用SPSS13.0统计软件对所有数据进行统计分析。 结果 ①KL-6在非OSAHS组和轻中度OSAHS组患者中血清水平差异无统计学意义（P=0.3610.05），重度OSAHS组患者中的血清水平明显高于非OSAHS组和轻中度OSAHS组（P=0.0000.05）；ET-1在非OSAHS组和轻中度OSAHS组患者中血清水平差异无统计学意义（P=0.2930.05），重度OSAHS组患者中的血清水平明显高于非OSAHS组和轻中度OSAHS组（P=0.0000.05）。②KL-6、ET-1血清水平与OSAHS患者AHI、LSaO2、BMI有相关性（P0.05），，与患者性别、年龄无关（P0.05）。③OSAHS患者血清中KL-6、ET-1水平呈正相关（r=0.942，P=0.0000.05）。 结论 单纯重度OSAHS患者存在血管内皮细胞损伤，与疾病严重程度相关，与患者性别、年龄无关。单纯重度OSAHS患者并发心血管并发症的风险性可能高于单纯轻中度OSAHS患者及非OSAHS患者；KL-6对于OSAHS病程后期或重症患者心血管并发症的风险性可能具有较好的预测作用。
[Abstract]:Objective to compare the levels of KL-6, et (ET-1) in peripheral blood of adult patients with severe, mild to moderate obstructive sleep apnea hypopnea syndrome (Obstructive sleep apnea-hypopnea syndrome,OSAHS) and non-OSAHS healthy controls. To investigate the relationship between vascular endothelial cell injury and simple OSAHS, and to understand the risk of cardiovascular complications in OSAHS and the role of KL-6 in the risk assessment of cardiovascular complications in OSAHS. Methods 75 snoring adults from March to October 2011 in Hunan Provincial people's Hospital were selected, of which 25 were from outpatient physical examination. According to Epworth narcolepsy scale (ESS) and Berlin sleep quality assessment questionnaire, they were classified into non-OSAHS normal control group. Another 50 patients were hospitalized in otorhinolaryngology head and neck surgery at the same time. According to the results of sleep respiratory monitoring (polysomnography,PSG), they were classified into mild to moderate OSAHS group and severe OSAHS group with 25 patients in each group. There were no obvious cardiovascular events, endocrine diseases, lung diseases, tumors and acute infection in all the subjects. There was no smoking and alcohol addiction, no major trauma in the near future, and no history of taking vasoactive drugs for a long time. All the subjects in the non-OSAHS group were investigated by questionnaire (ESS and Berlin sleep quality assessment questionnaire) or the patients in the OSAHS group were monitored by PSG. The elbow vein blood was taken on an empty stomach in the morning, and the upper serum was centrifuged and frozen in the refrigerator at-80 鈩
本文编号：2494708
[Abstract]:Objective to compare the levels of KL-6, et (ET-1) in peripheral blood of adult patients with severe, mild to moderate obstructive sleep apnea hypopnea syndrome (Obstructive sleep apnea-hypopnea syndrome,OSAHS) and non-OSAHS healthy controls. To investigate the relationship between vascular endothelial cell injury and simple OSAHS, and to understand the risk of cardiovascular complications in OSAHS and the role of KL-6 in the risk assessment of cardiovascular complications in OSAHS. Methods 75 snoring adults from March to October 2011 in Hunan Provincial people's Hospital were selected, of which 25 were from outpatient physical examination. According to Epworth narcolepsy scale (ESS) and Berlin sleep quality assessment questionnaire, they were classified into non-OSAHS normal control group. Another 50 patients were hospitalized in otorhinolaryngology head and neck surgery at the same time. According to the results of sleep respiratory monitoring (polysomnography,PSG), they were classified into mild to moderate OSAHS group and severe OSAHS group with 25 patients in each group. There were no obvious cardiovascular events, endocrine diseases, lung diseases, tumors and acute infection in all the subjects. There was no smoking and alcohol addiction, no major trauma in the near future, and no history of taking vasoactive drugs for a long time. All the subjects in the non-OSAHS group were investigated by questionnaire (ESS and Berlin sleep quality assessment questionnaire) or the patients in the OSAHS group were monitored by PSG. The elbow vein blood was taken on an empty stomach in the morning, and the upper serum was centrifuged and frozen in the refrigerator at-80 鈩
本文编号：2494708
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