利多卡因不同给药途径辅助治疗耳鸣疗效的Meta分析

发布时间：2019-06-08 10:34

【摘要】：目的:对利多卡因静脉注射、鼓室给药、穴位注射等不同给药途径治疗耳鸣的文献进行综合评价,评估利多卡因在耳鸣综合治疗中的应用价值。方法:检索中国知网、万方、维普、Pubmed、SciVerse ScienceDirect、Springer、OVID等数据库,筛选出利多卡因治疗耳鸣的文献进行严格质量评价和资料提取,采用Revman5.2软件对文献相关指标进行Meta分析。结果:共纳入文献16篇,1 203例患者,其中中文文献14篇,英文文献2篇。耳鸣患者病程7h~20年,疗效的评估主要依据响度分级、严重程度量表或主观感受。所有文献均未具体提及疗效维持时间,仅以"短期"、"较短"等词加以说明。其中静脉注射组133例,治疗总有效率为73.4%(98例);鼓室给药组50例,总有效率为74.0%(37例);穴位注射组332例,总有效率为87.7%(291例)。各对照组例数分别为125、40和326例,总有效率分别为42.4%、50.0%和58.3%。Meta分析结果显示,利多卡因经3种不同给药方式治疗耳鸣的总有效率均高于传统药物(P0.05)。结论:利多卡因不同给药途径尽管作用维持时间短,但均有一定耳鸣抑制作用。其作为耳鸣综合治疗的辅助措施,有助于缩短适应耳鸣的时间而非消除耳鸣,临床应用中应注意分析。
[Abstract]:Objective: to evaluate the literature of lidocaine intravenous injection, tympanic administration and acupoint injection in the treatment of tinnitus, and to evaluate the value of lidocaine in the comprehensive treatment of tinnitus. Methods: the literature of lidocaine in the treatment of tinnitus was selected for strict quality evaluation and data extraction by searching the databases of China knowledge Network, Wanfang, Vipp, Pubmed,SciVerse ScienceDirect,Springer,OVID and so on. Meta software was used to analyze the related indexes of the literature. Results: a total of 16 articles and 1 203 patients were included in the literature, 14 in Chinese and 2 in English. The course of tinnitus was 7h~20 year. The evaluation of curative effect was mainly based on loudness grade, severity scale or subjective feeling. All the literatures did not specifically mention the duration of curative effect, only with the words "short" and "short". Among 133 cases in intravenous injection group, the total effective rate was 73.4% (98 cases), the total effective rate was 74.0% (37 cases) in tympanic injection group (50 cases), and the total effective rate was 87.7% (291 cases) in acupoint injection group (332 cases). The number of cases in each control group was 125, 40 and 326. the total effective rate was 42.4%. The results of 58.3%.Meta analysis and analysis showed that the total effective rate was 42.4%. The total effective rate of lidocaine in the treatment of tinnitus was higher than that of traditional drugs (P 0.05). Conclusion: lidocaine has a certain inhibitory effect on tinnitus, although the effect of lidocaine is short. As an auxiliary measure of comprehensive treatment of tinnitus, it is helpful to shorten the time to adapt to tinnitus rather than eliminate tinnitus, and attention should be paid to the analysis in clinical application.
【作者单位】：上海中医药大学附属岳阳中西医结合医院耳鼻咽喉科;
【基金】：上海市市级医院新兴前沿技术联合攻关项目任务书(No:SHDC12014125) 上海市市属博士学科点建设基金(No:B201408)
【分类号】：R764.45

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