健康年轻人慢跑前后前房形态的变化

发布时间：2019-06-18 22:56

【摘要】：目的分析Pentacam三维眼前节分析仪测量健康年轻志愿者前房容积（anterior chambervolume，ACV）、中央前房深度（central anterior chamber depth，CACD）、周边前房深度（peripheral anterior chamber depth，PACD）、前房角（anterior chamber angle，ACA）、瞳孔直径（pupil diameter，PD）等前房形态生物学参数的重复性。方法于2011年10月-2011年11月连续收集健康志愿者30例（30只眼），年龄18～27岁。其中，男性15例（平均年龄22.56±3.31岁），女性15例（平均年龄20.57±1.78岁）。使用Pentacam三维眼前节分析仪连续测量前房形态3次，，选取Qs为OK的3次测量结果。采用SPSS13.0统计软件对数据进行处理。首先对数据进行Shapiro-Wilk正态分布检验，并用正态Q-Q图（Normal Q-Q Plots）对前房形态各生物学参数数据分别进行绘图；采用组内相关系数（intraclass correlation coefficients，ICC）评估Pentacam三维眼前节分析仪测量前房形态的重复性；并对前房形态各生物学参数的3组数据进行相关性分析。结果对前房形态各生物学参数数据进行Shapiro-Wilk正态分布检验，P值（Sig.）均＞0.01，提示呈正态分布。Pentacam三维眼前节分析仪对30只正常眼连续测量3次的结果分析，ACV、CACD、PACD0°、PACD90°、PACD180°、PACD270°、ACA、PD的组内相关系数ICC分别为0.986、0.985、0.989、0.954、0.989、0.991、0.956、0.929。前房形态各生物学参数的3组数据进行相关性分析显示，三次测量之间彼此存在高度相关性，r值均大于0.800（双侧P值均为0.000）。结论 Pentacam三维眼前节分析仪测量健康年轻志愿者的前房容积、中央前房深度、周边前房深度、前房角时重复性好，表现出较好的一致性。在测量瞳孔直径时重复性欠良好，可能与仪器原理方面和（或）生理因素有关。目的使用Pentacam三维眼前节分析仪测量健康年轻人慢跑前后中央前房深度、周边前房深度、前房容积、前房角、瞳孔直径的大小，量化分析其变化规律，为前房形态动态变化研究提供资料。方法 58例健康志愿者（58眼），男性16例（平均年龄22.56±3.31岁），女性42例（平均年龄20.57±1.78岁），排除眼部器质性疾病及全身系统性疾病。按照Karvonen方法慢跑20min，慢跑前、慢跑结束停止瞬间0min及之后5min、15min、30min、60min使用Pentacam三维眼前节分析仪观察前房形态，其生物学参数包括前房容积（anteriorchamber volume，ACV）、中央前房深度（central anterior chamber depth，CACD）、周边前房深度（peripheral anterior chamber depth，PACD）、前房角（anterior chamber angle，ACA）、瞳孔直径（pupil diameter，PD），同时使用非接触眼内压计测眼内压（intraocularpressure，IOP）、IOL-Master测量眼轴长度（axial length，AL）。应用SPSS13.0软件统计分析，首先对各参数在不同时间点的数据进行Lilliefors正态性检验；对各参数在不同时间点测量的数据进行重复测量设计的方差分析；用重复测量数据多重比较配对t检验法（Bonferroni法）对各参数在不同时间点数值进行两两比较；对慢跑前后各参数的变化进行直线相关分析。结果慢跑20min后，前房容积、中央前房深度、周边前房深度、前房角、瞳孔直径、眼内压、眼轴长度均有变化，且在慢跑停止瞬间0min变化最明显。前房容积增加(188.38±25.87μl/198.03±27.32μl, P＜0.05)，中央前房深度加深（3.19±0.25mm/3.21±0.25mm,P＜0.05），周边前房深度加深（2.37±0.25mm/2.43±0.25mm,P＜0.05），前房角变小（41.59±4.91°/40.69±4.68°,P＜0.05），瞳孔直径增大（2.98±0.38mm/3.34±0.59mm,P＜0.05），眼内压降低（14.50±2.87mm/12.78±2.51mm,P＜0.05），眼轴长度增长（24.95±0.89mm/24.97±0.89mm,P＜0.05）。慢跑前后前房容积的变化与周边前房深度的变化之间有相关关系，相关系数r值=0.565，为中度相关，即前房容积的变化与周边前房深度的变化呈正相关。中央前房深度的变化与周边前房深度的变化之间有相关关系，相关系数r值为0.392，即二者呈正相关。结论慢跑20min后前房深度加深、前房容积增加、瞳孔直径增大，同时伴眼轴长度增长，提示慢跑可以引起前房形态的动态变化，降低眼内压。其机制是否为血液动力学因素变化导致的脉络膜厚度变薄影响眼内容体积，需要进一步的研究证实。
[Abstract]:Purpose The anterior chamber volume (ACV), central anterior chamber depth (CACD), peripheral anterior chamber depth (PACD), anterior chamber angle (ACA), and pupil diameter (ppuil diaminete) were measured. Repetition of biological parameters in anterior chamber, such as r (PD) Sex. Methods 30 cases (30 eyes) of healthy volunteers were collected from October 2011 to November 2011, and the age of 18 ~ 27 years old, of which 15 (mean age: 22.56, 3.31 years) and 15 women (mean age 20.57%) 8-year-old).3 times of anterior chamber morphology were continuously measured using a Penacam three-dimensional anterior segment analyzer, and three measurements of Qs as OK were selected Volume results. Data entry using the SPSS13.0 statistical software The data was first examined by Shapiro-Wilk normal distribution and the biological parameters of the anterior chamber were plotted by normal Q-Q (Normal Q-Q Plots). The anterior chamber morphology of the anterior chamber was measured by using the intra-group correlation coefficient (ICC) to evaluate the anterior chamber morphology of the Penta 3-D anterior segment. Repeatability; and related to 3 sets of data for each biological parameter in the anterior chamber sex Analysis of the biological parameters of the anterior chamber with Shapiro-Wilk normal distribution test , the P value (Sig.) is greater than 0.01, The results of 3 times of continuous measurement of 30 normal eyes were analyzed, and the correlation coefficient (ICC) of ACV, CACD, PACD0 掳, PACD90 掳, PACD180 掳, PACD270 掳, ACA and PD was 0.986, 0.985, 0.989, 0.954, 0.989, 0.991, 0.95, respectively. 6. The correlation analysis between the three groups of the biological parameters of the anterior chamber morphology showed that there was a high correlation between the three measurements, and the r value was greater than 0.800 (bilateral P value 0 .000). Conclusion Penacam three-dimensional anterior segment analyzer measures the anterior chamber volume, central anterior chamber depth, peripheral anterior chamber depth, anterior chamber angle, and repeatability of healthy young volunteers Good, good consistency. The repeatability is good at the time of measuring the diameter of the pupil, which may be related to the principle of the instrument face and (or) related to physiological factors. The purpose of this study was to measure the changes of the anterior chamber depth, the anterior chamber depth, the anterior chamber volume, the anterior chamber angle and the pupil diameter before and after jogging in healthy young people using the Penacam three-dimensional anterior segment analyzer. in front of Methods 58 healthy volunteers (58 eyes),16 males (mean age 22.56 and 3.31 years) and 42 females (mean age of 20.57 and 1.78 years) were provided. ), excluding the organic and systemic diseases of the eye, jogging for 20 minutes according to the Karvonen method, jogging, stopping for 0 minutes and then 5 minutes,15 minutes,30 minutes, and 60 minutes using the Penacam three-dimensional anterior segment analyzer to observe the morphology of the anterior chamber, the biological parameters of the anterior chamber volume (ACV) and the central anterior chamber depth (central anterio). R-chamber depth (CACD), peripheral anterior chamber depth (PACD), anterior chamber angle (ACA), and pupil diameter (PD). The axial length (AL). The software of the SPSS13.0 software is used for statistical analysis, and the data of each parameter at different time points is first tested by Lillifors; for each parameter at different time the data of the point measurement is subjected to the analysis of variance of the repeated measurement design; the value of each parameter at different time points is compared by using the repeated measurement data multiple-comparison paired t-test method (Bonferroni method); slow-to-slow After 20 minutes of jogging, the anterior chamber volume, the central anterior chamber depth, the peripheral anterior chamber depth, the anterior chamber angle, the pupil diameter, the intraocular pressure, the eye axis length, The changes of anterior chamber volume (188.38, 25.87 & mu; l/ 198.03, 27.32 & mu; l, P <0.05), deep anterior chamber depth (3.19, 0.25 mm/ 3.21, 0.25 mm, P <0.05), and peripheral anterior chamber depth (2.37, 0.25 mm/ 2.43, 0.25 mm, P <0.05), and small anterior chamber angle (41.59%). 91 掳/ 40.69 (4.68 掳, P <0.05), pupil diameter increased (2.98, 0.38 mm/ 3.34, 0.59 mm, P <0.05), intraocular pressure decreased (14.50, 2.87 mm/ 12.78, 2.51 mm, P <0.05), and the length of the eye (24.95) 0.89 Mm/ 24.97 (0.89 mm, P <0.05). There was a correlation between the changes in the volume of the anterior chamber before and after the jogging and the change in the depth of the anterior chamber. The correlation coefficient, r, was 0.565, which was moderate. The change of the anterior chamber volume is positively correlated with the change of the anterior chamber depth. The change of the anterior chamber depth is related to the change of the anterior chamber depth. relationship The results showed that the depth of the anterior chamber, the volume of the anterior chamber, the diameter of the pupil and the length of the eye were increased after 20 minutes of jogging. The results suggest that jogging can cause the dynamic changes of the morphology of the anterior chamber and decrease the intraocular pressure. The mechanism of the mechanism is the change of hemodynamics.
【学位授予单位】：泰山医学院
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R775

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