强脉冲光治疗睑板腺功能障碍相关性干眼效果的研究
发布时间：2021-03-24 01:35
背景:干眼（dry eye,DED）是一种常见的眼部疾病。干眼需要及时的诊断和治疗,否则会导致危及视力的并发症,如角膜溃疡,角膜瘢痕、变薄,甚至角膜穿孔。早期诊断和治疗非常关键,可以防止并发症的产生,提高视觉质量。睑板腺是位于眼睑的大型皮脂腺,能够分泌脂质,形成泪膜表层,减少水分蒸发。上眼睑约有25-40个腺体,长约5.5毫米;下眼睑约有20-30个腺体,长约2毫米。睑板腺将脂质合成并分泌到泪膜中形成脂质层,这对于防止水液的过度蒸发至关重要。睑板腺功能障碍（meibomain gland dysfunction,MGD）是一种慢性弥漫性的睑板腺异常,包括末梢导管阻塞和/或腺体分泌的质/量变化,是干眼最常见的原因之一。强脉冲光（intense pulsed light,IPL）是一种非激光的高强度光源,大多数现代设备产生的光脉冲是通过充氙气室的电流脉冲产生的,而IPL是使用高性能氙灯产生长波长（通常在500到1200纳米范围内）的非相干光输出。IPL在医学领域的应用依赖于特定的能量吸收目标（发色团）能够从这一宽光谱的光波长（吸收带）吸收能量。其工作原理基于选择性的光热效应,热介导的辐射损...
【文章来源】：吉林大学吉林省 211工程院校 985工程院校 教育部直属院校
【文章页数】：84 页
【学位级别】：硕士
【文章目录】：
中文摘要
abstract
CHAPTER 1: INTRODUCTION
1.1 BACKGROUND
1.1.1 Meibomian Gland Dysfunction
1.2 RISK FACTOR
1.3 MECHANISM OF ACTION
1.4 CLASSIFICATION
1.5 TEAR FILM
1.6 PATHOPHYSIOLOGY
1.7 MANAGEMENT
1.8 COMPLICATIONS
CHAPTER 2: A LITERATURE REVIEW
2.1 MECHANISMS OF ACTION OF IPL
2.1.1 Thrombosis of abnormal blood vessels
2.1.2 Eradication of Demodex and reducing the bacterial load
2.1.3 Photomodulation
2.1.4 Effects on meibum
2.1.5 Effects on pro- and anti-inflammatory molecules andsuppression of MMPs
2.1.6 IPL induces hypoxic condition on meibomian gland
2.2 IPL ASSOCIATED BENEFITS
2.2.1 Intense pulsed light in patients with refractory meibomiangland dysfunction
2.2.2 IPL as a safe procedure for MGD
2.2.3 Significant improvement in the first IPL treatment
2.2.4 Effect of intense pulsed light therapy on tear proteins, lipids,and inflammatory markers in MGD
2.2.5 Effect on the meibum of MGD by IPL
CHAPTER 3: MATERIAL AND METHODS
3.1 OBJECTIVE OF THE STUDY
3.2 STUDY DESIGN
3.3 METHODS
3.4 DIAGNOSTIC CRITERIA FOR DRY EYE
3.5 INCLUSION CRITERIA
3.6 EXCLUSION CRITERIA
3.7 THERAPY PROCEDURE
3.8 STATISTICAL ANALYSIS
CHAPTER 4: RESULT
4.1 BASELINE CHARACTERISTICS
4.2 COMPARISON OF MEASUREMENT IN THE LEFT EYE AND RIGHT EYEWITH BEFORE AND AFTER IPL-MGX TREATMENTS
4.3 COMPARISON OF MEASUREMENT ACCOUNTING FOR THE CORRELATION OF THE LEFT EYE AND THE RIGHT EYE OF THE SAMEPERSON USING A GENERALIZED ESTIMATING EQUATION
4.4 COMPARISON OF A PORTION OF THE MEIBOMIAN GLAND ACCOUNTING FOR THE UPPER AND LOWER EYELID AND THE LEFT ANDTHE RIGHT EYE OF THE SAME PATIENT
4.5 DESCRIPTION OF RESULT
CHAPTER 5: DISCUSSION
CHAPTER 6: CONCLUSION
REFERENCE
AUTHOR’S INTRODUCTION
ACKNOWLEDGEMENT
本文编号：3096799
【文章来源】：吉林大学吉林省 211工程院校 985工程院校 教育部直属院校
【文章页数】：84 页
【学位级别】：硕士
【文章目录】：
中文摘要
abstract
CHAPTER 1: INTRODUCTION
1.1 BACKGROUND
1.1.1 Meibomian Gland Dysfunction
1.2 RISK FACTOR
1.3 MECHANISM OF ACTION
1.4 CLASSIFICATION
1.5 TEAR FILM
1.6 PATHOPHYSIOLOGY
1.7 MANAGEMENT
1.8 COMPLICATIONS
CHAPTER 2: A LITERATURE REVIEW
2.1 MECHANISMS OF ACTION OF IPL
2.1.1 Thrombosis of abnormal blood vessels
2.1.2 Eradication of Demodex and reducing the bacterial load
2.1.3 Photomodulation
2.1.4 Effects on meibum
2.1.5 Effects on pro- and anti-inflammatory molecules andsuppression of MMPs
2.1.6 IPL induces hypoxic condition on meibomian gland
2.2 IPL ASSOCIATED BENEFITS
2.2.1 Intense pulsed light in patients with refractory meibomiangland dysfunction
2.2.2 IPL as a safe procedure for MGD
2.2.3 Significant improvement in the first IPL treatment
2.2.4 Effect of intense pulsed light therapy on tear proteins, lipids,and inflammatory markers in MGD
2.2.5 Effect on the meibum of MGD by IPL
CHAPTER 3: MATERIAL AND METHODS
3.1 OBJECTIVE OF THE STUDY
3.2 STUDY DESIGN
3.3 METHODS
3.4 DIAGNOSTIC CRITERIA FOR DRY EYE
3.5 INCLUSION CRITERIA
3.6 EXCLUSION CRITERIA
3.7 THERAPY PROCEDURE
3.8 STATISTICAL ANALYSIS
CHAPTER 4: RESULT
4.1 BASELINE CHARACTERISTICS
4.2 COMPARISON OF MEASUREMENT IN THE LEFT EYE AND RIGHT EYEWITH BEFORE AND AFTER IPL-MGX TREATMENTS
4.3 COMPARISON OF MEASUREMENT ACCOUNTING FOR THE CORRELATION OF THE LEFT EYE AND THE RIGHT EYE OF THE SAMEPERSON USING A GENERALIZED ESTIMATING EQUATION
4.4 COMPARISON OF A PORTION OF THE MEIBOMIAN GLAND ACCOUNTING FOR THE UPPER AND LOWER EYELID AND THE LEFT ANDTHE RIGHT EYE OF THE SAME PATIENT
4.5 DESCRIPTION OF RESULT
CHAPTER 5: DISCUSSION
CHAPTER 6: CONCLUSION
REFERENCE
AUTHOR’S INTRODUCTION
ACKNOWLEDGEMENT
本文编号：3096799
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