外周血绝对单核细胞计数、血小板与绝对淋巴细胞计数比值在原发鼻腔NK/T细胞淋巴瘤中的预后分析
发布时间：2021-07-09 17:54
背景与目的:NK/T细胞淋巴瘤（natural killer/T-cell lymphoma,NKTCL）为恶性淋巴瘤中较少见的一种类型,其在临床表现及整体疗效上差别较大,目前尚无确切的危险分层指导预后。该研究旨在探索治疗前外周血绝对单核细胞计数（absolute monocyte count,AMC）、血小板与绝对淋巴细胞计数比值（platelet-lymphocyte ratio,PLR）在原发鼻腔NKTCL预后中的意义,为患者提供更确切的危险分层,从而选择恰当的治疗方案改善预后。方法:收集天津医科大学肿瘤医院2008年1月—2013年12月初诊的132例原发鼻腔NKTCL患者的临床资料。回顾性分析治疗前外周血AMC、PLR与患者5年总生存率（overall survival,OS）及无进展生存率（progression-free survival,PFS）之间的关系。患者预后的影响因素采用单因素分析和Cox比例风险模型多因素分析。结果:治疗前外周血AMC、PLR在原发鼻腔NKTCL患者的预后分层中均具有重要作用。AMC小于0.5×109个/L组患者的预后明显优于AMC大于等于0....
【文章来源】：中国癌症杂志. 2017,27(05)北大核心CSCD
【文章页数】：7 页
【部分图文】：
不同AMC患者的5年OS及PFSFig.1The5-yearOSandPFSofallpatientsstratifiedbytheAMCatdiagnosis
380表3单因素及多因素分析与136例原发鼻腔NKTCL患者OS相关的危险因素Tab.3UnivariateanalysisandmultivariateCox-regressionanalysisofvariablesrelatedtoOSin136patientswithprimarynasalnaturalkiller/T-celllymphomaPrognosisUnivariateanalysisMultivariateanalysisHR(95%CI)PvalueHR(95%CI)PvalueGender0.477(1.286-3.415)0.0031.003(0.565-1.783)0.991Age2.560(1.453-4.512)0.0011.647(0.922-2.941)0.920Bsymptoms1.708(0.993-2.938)0.053--AnnArborstage8.324(4.848-14.291)0.0008.138(3.991-16.596)0.000ECOGscorestandard13.088(6.076-28.189)0.0007.242(3.035-17.285)0.000LDH2.188(1.333-3.591)0.0021.151(0.630-2.103)0.646AMC2.440(1.451-4.101)0.0011.946(1.117-3.391)0.019PLT1.411(0.860-2.314)0.173--PLR4.910(2.711-8.894)0.0004.197(2.253-7.818)0.000陈亚芳，等.外周血绝对单核细胞计数、血小板与绝对淋巴细胞计数比值在原发鼻腔NK/T细胞淋巴瘤中的预后分析图2不同PLR患者的5年OS及PFSFig.2The5-yearOSandPFSofallpatientsstratifiedbythePLRatdiagnosisA:The5-yearOS;B:The5-yearPFS图3在不同危险分层下患者的5年OS及PFSFig.3The5-yearOSandPFSofallpatientsstratifiedbyAMCandPLRatdiagnosisA:The5-yearOS;B:The5-yearPFS
380表3单因素及多因素分析与136例原发鼻腔NKTCL患者OS相关的危险因素Tab.3UnivariateanalysisandmultivariateCox-regressionanalysisofvariablesrelatedtoOSin136patientswithprimarynasalnaturalkiller/T-celllymphomaPrognosisUnivariateanalysisMultivariateanalysisHR(95%CI)PvalueHR(95%CI)PvalueGender0.477(1.286-3.415)0.0031.003(0.565-1.783)0.991Age2.560(1.453-4.512)0.0011.647(0.922-2.941)0.920Bsymptoms1.708(0.993-2.938)0.053--AnnArborstage8.324(4.848-14.291)0.0008.138(3.991-16.596)0.000ECOGscorestandard13.088(6.076-28.189)0.0007.242(3.035-17.285)0.000LDH2.188(1.333-3.591)0.0021.151(0.630-2.103)0.646AMC2.440(1.451-4.101)0.0011.946(1.117-3.391)0.019PLT1.411(0.860-2.314)0.173--PLR4.910(2.711-8.894)0.0004.197(2.253-7.818)0.000陈亚芳，等.外周血绝对单核细胞计数、血小板与绝对淋巴细胞计数比值在原发鼻腔NK/T细胞淋巴瘤中的预后分析图2不同PLR患者的5年OS及PFSFig.2The5-yearOSandPFSofallpatientsstratifiedbythePLRatdiagnosisA:The5-yearOS;B:The5-yearPFS图3在不同危险分层下患者的5年OS及PFSFig.3The5-yearOSandPFSofallpatientsstratifiedbyAMCandPLRatdiagnosisA:The5-yearOS;B:The5-yearPFS
本文编号：3274207
【文章来源】：中国癌症杂志. 2017,27(05)北大核心CSCD
【文章页数】：7 页
【部分图文】：
不同AMC患者的5年OS及PFSFig.1The5-yearOSandPFSofallpatientsstratifiedbytheAMCatdiagnosis
380表3单因素及多因素分析与136例原发鼻腔NKTCL患者OS相关的危险因素Tab.3UnivariateanalysisandmultivariateCox-regressionanalysisofvariablesrelatedtoOSin136patientswithprimarynasalnaturalkiller/T-celllymphomaPrognosisUnivariateanalysisMultivariateanalysisHR(95%CI)PvalueHR(95%CI)PvalueGender0.477(1.286-3.415)0.0031.003(0.565-1.783)0.991Age2.560(1.453-4.512)0.0011.647(0.922-2.941)0.920Bsymptoms1.708(0.993-2.938)0.053--AnnArborstage8.324(4.848-14.291)0.0008.138(3.991-16.596)0.000ECOGscorestandard13.088(6.076-28.189)0.0007.242(3.035-17.285)0.000LDH2.188(1.333-3.591)0.0021.151(0.630-2.103)0.646AMC2.440(1.451-4.101)0.0011.946(1.117-3.391)0.019PLT1.411(0.860-2.314)0.173--PLR4.910(2.711-8.894)0.0004.197(2.253-7.818)0.000陈亚芳，等.外周血绝对单核细胞计数、血小板与绝对淋巴细胞计数比值在原发鼻腔NK/T细胞淋巴瘤中的预后分析图2不同PLR患者的5年OS及PFSFig.2The5-yearOSandPFSofallpatientsstratifiedbythePLRatdiagnosisA:The5-yearOS;B:The5-yearPFS图3在不同危险分层下患者的5年OS及PFSFig.3The5-yearOSandPFSofallpatientsstratifiedbyAMCandPLRatdiagnosisA:The5-yearOS;B:The5-yearPFS
380表3单因素及多因素分析与136例原发鼻腔NKTCL患者OS相关的危险因素Tab.3UnivariateanalysisandmultivariateCox-regressionanalysisofvariablesrelatedtoOSin136patientswithprimarynasalnaturalkiller/T-celllymphomaPrognosisUnivariateanalysisMultivariateanalysisHR(95%CI)PvalueHR(95%CI)PvalueGender0.477(1.286-3.415)0.0031.003(0.565-1.783)0.991Age2.560(1.453-4.512)0.0011.647(0.922-2.941)0.920Bsymptoms1.708(0.993-2.938)0.053--AnnArborstage8.324(4.848-14.291)0.0008.138(3.991-16.596)0.000ECOGscorestandard13.088(6.076-28.189)0.0007.242(3.035-17.285)0.000LDH2.188(1.333-3.591)0.0021.151(0.630-2.103)0.646AMC2.440(1.451-4.101)0.0011.946(1.117-3.391)0.019PLT1.411(0.860-2.314)0.173--PLR4.910(2.711-8.894)0.0004.197(2.253-7.818)0.000陈亚芳，等.外周血绝对单核细胞计数、血小板与绝对淋巴细胞计数比值在原发鼻腔NK/T细胞淋巴瘤中的预后分析图2不同PLR患者的5年OS及PFSFig.2The5-yearOSandPFSofallpatientsstratifiedbythePLRatdiagnosisA:The5-yearOS;B:The5-yearPFS图3在不同危险分层下患者的5年OS及PFSFig.3The5-yearOSandPFSofallpatientsstratifiedbyAMCandPLRatdiagnosisA:The5-yearOS;B:The5-yearPFS
本文编号：3274207
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