基质金属蛋白酶-7、糖类抗原19-9在胰腺癌与肿块型胰腺炎中的表达及鉴别价值

发布时间：2017-12-31 07:09

本文关键词：基质金属蛋白酶-7、糖类抗原19-9在胰腺癌与肿块型胰腺炎中的表达及鉴别价值　出处：《中国老年学杂志》2016年17期 　论文类型：期刊论文

【摘要】：目的探讨基质金属蛋白酶(MMP)-7及糖类抗原(CA)19-9在胰腺癌(PC)与肿块型胰腺炎(MFP)组织及血清中的表达及鉴别意义。方法手术切除PC标本27例,MFP标本15例,胰腺正常组织30例作为对照组。免疫组织化学染色SP法检测3组组织中MMP-7的表达,并用化学发光免疫法检测术前血清CA19-9的含量。结果 PC组、MFP组血清CA-199水平明显高于对照组(P均0.05),但PC组与MFP组差异无统计学意义。PC组MMP-7阳性表达率明显高于MFP组及对照组(P均0.05)。结论 CA19-9是诊断PC的敏感指标,但特异性不强,独立鉴别PC与MFP的准确性不高。MMP-7可能在癌前病变MFP发展为PC中起重要作用,MMP-7有可能作为生物学指标来鉴别PC与MFP。
[Abstract]:Objective to investigate the role of matrix metalloproteinase (MMP-7) and carbohydrate antigen (CA19-9) in pancreatic carcinoma (PC) and mass pancreatitis (MFP). Methods 27 cases of PC specimens were surgically resected. 15 cases of MFP and 30 cases of normal pancreas were used as control group. Immunohistochemistry SP method was used to detect the expression of MMP-7 in 3 groups. The level of serum CA19-9 in PC group was significantly higher than that in control group (P 0.05). But there was no significant difference between PC group and MFP group. The positive expression rate of MMP-7 in PC group was significantly higher than that in MFP group and control group (P 0.05). Conclusion CA19-9 is a sensitive index for the diagnosis of PC. But the specificity is not strong, and the accuracy of independent differentiation between PC and MFP is not high. MMP-7 may play an important role in the development of precancerous MFP into PC. MMP-7 may be used as a biological marker to distinguish PC from MFP.
【作者单位】：佳木斯大学附属第一医院普外科;佳木斯大学附属第一医院消化科;
【基金】：佳木斯大学校级重点课题(No.Sz2013-006)
【分类号】：R735.9;R576
【正文快照】： 胰腺癌(PC)是临床最常见且恶性程度极高的肿瘤之一,居全球恶性肿瘤死因的第4位,消化系统恶性肿瘤的第2位〔1〕。美国癌症协会(ACS)监测与卫生研究部指出,大多数癌症死亡率逐年下降,而PC死亡率却一直在上升,为致死性最强的癌症之一,大多患者确诊1年内死亡,与该病一级预防、早期

【相似文献】