消化性溃疡患者外周血细胞免疫及体液免疫功能变化分析

发布时间：2017-12-31 00:05

本文关键词：消化性溃疡患者外周血细胞免疫及体液免疫功能变化分析　出处：《中国全科医学》2016年20期 　论文类型：期刊论文

【摘要】：目的探讨消化性溃疡患者外周血细胞免疫及体液免疫功能的变化及临床意义。方法选择2014年1月—2015年1月杭州师范大学附属医院门诊及住院的连续经胃镜确诊的消化性溃疡患者122例为溃疡组,另选择同期体检中心体检健康者70例为对照组,溃疡组患者根据是否感染幽门螺杆菌分为幽门螺杆菌阳性亚组(Hp+亚组)85例和幽门螺杆菌阴性亚组(Hp-亚组)37例,根据是否出血分为出血亚组58例和未出血亚组64例。检测外周血细胞免疫指标(包括CD_3、CD_4、CD_8、CD_4/CD_8、CD_(19)、CD_(56))及体液免疫指标(IgG、IgA、IgM、IgE、C_3、C_4)水平,出血亚组中30例大便隐血试验阳性患者大便隐血试验转阴后复查外周血细胞免疫指标及体液免疫指标。结果溃疡组患者外周血CD_3、CD_4、CD_4/CD_8、CD_(19)、CD_(56)、C_3、C_4水平较对照组降低,IgG水平较对照组升高(P0.05);Hp+亚组患者外周血CD_3、CD_4、CD_8、CD_(19)、IgM、IgE水平较Hp-亚组升高,CD_4/CD_8较Hp-亚组降低(P0.05);出血亚组患者外周血CD_3、CD_4水平、CD_4/CD_8较未出血亚组降低(P0.05)。大便隐血试验阳性患者转阴后外周血CD_3、CD_4、CD_8、CD_(19)、CD_(56)、C_3、C_4水平较治疗前升高,IgG、IgM水平较治疗前降低(P0.05)。结论消化性溃疡患者存在免疫功能调节紊乱,幽门螺杆菌感染可促使机体产生强烈的免疫反应,急性出血后免疫功能处于抑制状态,止血后免疫功能有所恢复。
[Abstract]:Objective to investigate the changes in peripheral blood of patients with digestive ulcer cell immunity and humoral immune function and its clinical significance. Methods the Affiliated Hospital from January 2014 to January 2015 Hangzhou Normal University Hospital and by the patients with peptic ulcer diagnosed by gastroscopy in 122 cases of ulcer group, selected 70 healthy cases as control group. Ulcer group according to whether patients with Helicobacter pylori infection for Helicobacter pylori positive subgroup (Hp+ subgroup) and 85 cases of Helicobacter pylori negative subgroup (Hp- subgroup) 37 cases, according to whether the bleeding is divided into hemorrhage sub group 58 cases and 64 cases without bleeding subgroups. Detection of peripheral blood cell immune index (including CD_3, CD_4, CD_8, CD_4/CD_8, CD_ (19), CD_ (56)) and humoral immunity index (IgG, IgA, IgM, IgE, C_3, C_4), 30 cases of hemorrhage of fecal occult blood test in patients with positive stool blood test negative review after the hidden subgroup of peripheral blood fine Cell immune and humoral immune indices. The ulcer group in peripheral blood of patients with CD_3, CD_4, CD_4/CD_8, CD_ (19), CD_ (56), C_3, C_4 were lower than those in control group, the level of IgG was higher than the control group (P0.05); peripheral blood CD_3, Hp+ subgroup CD_4, CD_8, CD_ (19), IgM, IgE levels than the Hp- sub group increased, CD_4/CD_8 decreased compared with Hp- subgroup (P0.05); hemorrhage of peripheral blood CD_3, a subgroup of patients with a level of CD_4, CD_4/CD_8 sub group decreased compared with non hemorrhage (P0.05). Serum CD_3, fecal occult blood test positive negative patients after CD_4, CD_8, CD_ (19), CD_ (56), C_3, C_4 levels increased, compared with before treatment, IgG, IgM levels lower than before treatment (P0.05). Conclusion the patients with peptic ulcer in regulating immune function disorder, can promote the body to produce a strong immune response of Helicobacter pylori infection, acute hemorrhage after the immune function in the inhibitory state, have recovery of immune function after hemostasis.

【作者单位】：杭州师范大学附属医院消化内科;
【分类号】：R573.1
【正文快照】： 消化性溃疡是一种多发病、常见病,好发于胃和十二指肠。免疫因素是否参与了消化性溃疡的发生与发展,是目前国内外研究的焦点之一[1-2],且一直存在争议,免疫功能调节具有双向性,其亢进或低下与消化性溃疡的关系尚不清楚[3]。为此,本研究检测消化性溃疡患者外周血细胞免疫指标及

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