2011-2013年上海西区哨点医院成人急性腹泻细菌感染的病原学分析

发布时间：2018-01-02 16:05

本文关键词：2011-2013年上海西区哨点医院成人急性腹泻细菌感染的病原学分析　出处：《中华医院感染学杂志》2016年22期 　论文类型：期刊论文

【摘要】：目的了解上海市西区哨点医院成人急性腹泻病细菌感染的菌群分布及变化趋势,有针对性地进行急性腹泻病的预防控制。方法选取2011年1月-2013年12月上海西区哨点医院肠道门诊未使用抗菌药物的急性腹泻患者2 091例,采集粪标本进行培养并分离常见肠道致病细菌(副溶血弧菌、大肠埃希菌、沙门菌属、空肠弯曲菌和志贺氏菌属),由长宁区疾病预防控制中心对各医院分离的阳性菌株进行复核并保存。结果 671例患者粪便培养阳性,阳性率达32.1%,培养出病原菌671株,居前是副溶血弧菌、大肠埃希菌、沙门菌属和志贺菌属,其所占比例分别为33.8%、22.1%、21.5%和10.3%;其中,大肠埃希菌主要为肠产毒性大肠杆菌(ETEC),占74.3%(110/148);沙门菌属以肠炎沙门氏菌最为常见,占44.4%(64/144);志贺氏菌属以宋氏志贺菌为主,占84.1%(58/69);21~30岁患者的病原菌检出率最高,达(29.5%);各季节病原菌检出以7~9月份最多,占68.70%(461/671)。结论上海市西区成人急性腹泻患者有明显的季节性,青年为主,大肠埃希菌感染呈上升趋势,应主动对重点人群有针对性地开展有效的腹泻病预防控制工作。
[Abstract]:Objective to understand the Western District of Shanghai City sentinel hospital adult acute diarrhea bacterial flora distribution and change trend in prevention of acute diarrhea disease control. Methods from January 2011 December -2013 Shanghai west of acute diarrhea in sentinel hospitals without intestinal clinic use of antibacterial drugs in 2091 cases, collecting fecal specimens for culture and the separation of common intestinal pathogenic bacteria (Vibrio parahaemolyticus, Escherichia coli, Salmonella, Campylobacter and Shigella), positive strains from Changning District disease prevention and control center of the hospital to check and save the separation. Results 671 cases of patients with fecal culture positive, the positive rate was 32.1%. The pathogens were isolated from 671 the top line is Vibrio parahaemolyticus, Escherichia coli, Salmonella and Shigella, the proportion was 33.8%, 22.1%, 21.5% and 10.3%; among them, Escherichia coli is mainly enterototxigenic Enterotoxigenic Escherichia coli (ETEC), 74.3% (110/148); Salmonella in Salmonella Enteritidis is the most common, accounting for 44.4% (64/144); Shigella with Shigella sonnei, accounted for 84.1% (58/69); pathogen 21~30 years old patients with the highest positive rate (29.5%) of each season; detection of the pathogen to 7~9 most of the month, accounting for 68.70% (461/671) in patients with acute diarrhea in adults. Western Shanghai conclusion is seasonal, obvious youth. The Escherichia coli infection is on the rise, should take the initiative to focus groups to carry out targeted pre effective anti diarrhea disease control work.

【作者单位】：上海市同仁医院感染科;上海市长宁区疾病预防控制中心传染病防治科;上海市公共卫生临床中心病原体检测与生物安全部;
【分类号】：R516.1
【正文快照】： 感染性腹泻历来以高发病率和流行广泛为特点,在世界各地均有发生,尤以发展中国家为甚[1-3]。据WHO估计,全世界每天约有数千万人发病,每年有17亿例次腹泻病发生在世界各地,因严重腹泻而死亡的估计有200多万病例[3-5]。感染性腹泻是临床上最常见的消化道感染性疾病之一,在我国,

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