培菲康与铋剂四联方案在老年消化性溃疡幽门螺杆菌感染治疗中的应用探讨

发布时间：2018-01-02 18:27

本文关键词：培菲康与铋剂四联方案在老年消化性溃疡幽门螺杆菌感染治疗中的应用探讨　出处：《中华医院感染学杂志》2016年14期 　论文类型：期刊论文

【摘要】：目的研究培菲康与铋剂四联方案在老年消化性溃疡幽门螺杆菌感染患者中的临床治疗效果,为临床提供依据。方法选取2014年11月-2016年1月医院诊治的68例老年消化性溃疡幽门螺杆菌(HP)感染患者,随机分为对照组和试验组,每组34例;对照组采用铋剂四联方案治疗,试验组在对照组基础上联合培菲康辅助治疗,比较两组临床疗效。结果试验组治疗疗效率为91.18%,显著高于对照组的73.53%(P0.05);两组患者治疗前血锌浓度差异无统计学意义;试验组治疗后2周、4周血锌浓度水平,显著低于对照组(P0.05);试验组治疗后不良反应发生率为14.71%,显著低于对照组的35.92%(P0.05)。结论老年消化性溃疡HP感染患者在铋剂四联方案治疗基础上联合培菲康辅助治疗效果理想,不良反应发生率低,值得推广应用。
[Abstract]:Objective to study the clinical effect of the tetralogy of peeficam and bismuth in the treatment of Helicobacter pylori infection in the elderly patients with peptic ulcer. Methods from November 2014 to January 2016, 68 patients with Helicobacter pylori (HP) infection in elderly peptic ulcer patients were randomly divided into two groups: control group and experimental group. 34 cases in each group; The control group was treated with bismuth tetralogen and the experimental group was treated with peeficam on the basis of the control group, and the clinical efficacy of the two groups was compared. Results the effective rate of the trial group was 91.18%. It was significantly higher than that of the control group (73.53). There was no significant difference in serum zinc concentration between the two groups before treatment. The serum zinc concentration in the experimental group was significantly lower than that in the control group at 2 weeks and 4 weeks after treatment, which was significantly lower than that in the control group (P 0.05). The incidence of adverse reactions after treatment was 14.71% in the trial group. Conclusion in the elderly patients with peptic ulcer HP infection, the efficacy is ideal on the basis of bismuth tetralogy regimen combined with peeficam adjuvant therapy. The incidence of adverse reactions is low and worth popularizing.
【作者单位】：湖州市长兴县人民医院药剂科;中国药科大学理学院;
【基金】：浙江省医学会临床科研基金项目(2013ZYC-A84)
【分类号】：R573.1
【正文快照】： 消化性溃疡是临床上常见的疾病,在老年人群中比较普遍。相关研究显示[1]:消化性溃疡患者症状年龄60岁老年占40%。文献报道显示[2]:幽门螺杆菌(HP)与消化性溃疡关系密切,且在日常生活中比较普遍。数据显示[3-4]:发达国家HP感染率为25%~50%,而发展中国家HP感染率为70.0%~90.0%

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