利福昔明片联合双歧杆菌三联活菌胶囊治疗中老年急性感染性腹泻84例

发布时间：2018-02-10 13:21

本文关键词： 利福昔明双歧杆菌三联活菌胶囊中老年急性感染性腹泻　出处：《中国新药杂志》2016年09期 　论文类型：期刊论文

【摘要】：目的:探讨利福昔明片联合双歧杆菌三联活菌胶囊对中老年急性感染性腹泻的临床疗效。方法:选择2014年5月至2015年12月期间在我院就诊的84例中老年急性感染性腹泻患者,按就诊次序随机分为两组,其中观察组给予利福昔明片联合双歧杆菌三联活菌胶囊口服,对照组给予双歧杆菌三联活菌胶囊口服,对比两组患者不同治疗方案的疗效、症状积分、平均止泻时间以及不良反应发生率。结果:总有效率观察组92.86%(39/42),对照组76.19%(32/42),差异显著(P0.05);治疗后症状积分观察组(1.42±0.82)分,对照组(2.36±1.93)分,差异显著(P0.05);平均止泻时间观察组(40.66±11.45)h,对照组(48.23±12.28)h,差异显著(P0.05);不良反应发生率观察组4.76%(2/42),对照组7.14%(3/42),无显著差异。结论:治疗中老年急性感染性腹泻,采用利福昔明片联合双歧杆菌三联活菌胶囊可提高治疗效果,缩短止泻时间,减轻患者痛苦,同时不良反应率低,用药安全。
[Abstract]:Objective: to investigate the clinical efficacy of rifaximin tablets combined with Bifidobacterium triple viable capsule in the treatment of acute infectious diarrhea in middle-aged and old people. Methods: 84 patients with acute infectious diarrhea of middle and old age were selected from May 2014 to December 2015 in our hospital. Two groups were randomly divided into two groups according to the order of treatment. The observation group was given rifaximin tablets combined with bifidobacterium triple live bacillus capsule, and the control group was given bifidobacterium triple living bacteria capsule. The curative effects of different treatment schemes were compared between the two groups. Results: the total effective rate of the observation group was 92.86 / 42%, while the control group was 76.19 / 32 / 42, the difference was significant (P0.05), the symptom score of observation group was 1.42 卤0.82 after treatment, and that of control group was 2.36 卤1.93). The mean time of stopping diarrhea in observation group was 40.66 卤11.45 min / h, and that in control group was 48.23 卤12.28 min / h, the difference was significant (P 0.05), and the incidence of adverse reactions was 4.76 / 42% in observation group and 7.14% / 42% in control group. Conclusion: the treatment of acute infectious diarrhea in middle-aged and old people, Rifaximin tablets combined with Bifidobacterium triple viable capsule can improve the therapeutic effect, shorten the time of stopping diarrhea, alleviate the pain of patients, at the same time, the adverse reaction rate is low and the medication is safe.
【作者单位】：解放军医学院;海军总医院;
【基金】：军队后勤科研计划重点项目(BHJ14J010)
【分类号】：R574.62

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