比阿培南治疗肝衰竭重度感染患者的效果研究

发布时间：2018-02-11 08:46

本文关键词： 比阿培南治疗肝衰竭重度感染　出处：《中华医院感染学杂志》2015年23期 　论文类型：期刊论文

【摘要】：目的研究肝衰竭重度感染患者病原菌的分布,探讨其危险因素、临床特点及治疗转归,评价比阿培南治疗肝衰竭重度感染患者的疗效性和安全性。方法选取2012年2月-2015年1月在医院住院的306例肝衰竭重度感染患者,对常见感染指标进行监测,并对采集的标本进行细菌培养,应用比阿培南治疗,观察临床表现变化、疗程及不良反应发生情况,数据采用SPSS 11.5软件进行统计分析。结果 306例肝衰竭重度感染患者中自发性细菌腹膜炎占64.71%,呼吸道感染占26.47%,其他部位感染占8.82%;大肠埃希菌在血液、腹水及尿液培养中分别占40.39%、58.69%、50.00%;而肺炎链球菌在痰液培养最常见为29.41%;应用比阿培南治疗一周总有效率为89.22%、痊愈率为63.73%,治疗两周总有效率为91.50%、痊愈率为86.27%。结论肝衰竭患者感染发生率高,预后差,最常见的重度感染为自发性细菌性腹膜炎;比阿培南治疗肝衰竭合并重度感染患者安全有效且不良反应少。
[Abstract]:Objective to study the distribution of pathogenic bacteria in patients with severe infection of liver failure, and to explore the risk factors, clinical characteristics and outcome of treatment. Objective: to evaluate the efficacy and safety of Biapenem in the treatment of severe infection of liver failure. Methods 306 patients with severe infection of liver failure who were hospitalized from February 2012 to January 2015 were selected and the common infection indexes were monitored. The samples were cultured and treated with Biapenem. The clinical manifestations, course of treatment and adverse reactions were observed. Results among the 306 patients with severe infection of liver failure, spontaneous bacterial peritonitis accounted for 64.71%, respiratory tract infection 26.47%, other infection 8.82%, Escherichia coli in blood. Ascitic fluid and urine culture accounted for 40.39 and 58.69 respectively, while Streptococcus pneumoniae was the most common in sputum culture 29.41. The total effective rate was 89.222.The cure rate was 63.730.The total effective rate for two weeks was 91.50 and the cure rate was 86.27.Conclusion the total effective rate is 89.22, the cure rate is 63.73, the total effective rate is 91.50 and the cure rate is 86.271.Conclusion liver failure is a disease of liver failure. The incidence of infection was high, The prognosis was poor and the most common severe infection was spontaneous bacterial peritonitis, which was safer, more effective and less adverse than Apenem in the treatment of liver failure complicated with severe infection.
【作者单位】：山东大学附属济南市传染病医院介入科;章丘市人民医院内科;山东大学附属济南市传染病医院肝病科;
【基金】：山东省科技厅研究基金资助项目(201409882)
【分类号】：R575.3

【参考文献】