特利加压素对比白蛋白对预防腹腔穿刺术后循环功能障碍的Meta分析

发布时间：2018-02-12 05:52

本文关键词： 特利加压素白蛋白腹腔穿刺术后循环功能障碍 Meta分析　出处：《重庆医科大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：对特利加压素预防腹腔穿刺术后循环功能障碍（post-paracentesis circulatory dysfunction，PPCD）的效果进行系统评价。方法：通过PubMed、EMbase、Cochrane Library和中国知网等数据库，检索2013年10月前发表的有关肝硬化合并大量腹水患者在腹腔穿刺大量放液（large-volume paracentesis，LVP）后使用并比较特利加压素与白蛋白预防PPCD效果的随机对照试验文献，并采用RevMan5.2.5软件进行Meta分析。结果：特利加压素组与白蛋白组相比，患者在LVP后平均动脉压、血浆醛固酮浓度、血清肌酐浓度、血清钠浓度及体重的变化无统计学差异。其加权均数差值（weighted mean difference，WMD）及95%置信区间（confidence interval，CI）分别为0.22（-2.02，2.45，，P=0.85）、-2.41（-188.26，183.44，P＝0.98）、2.02（-5.40，9.44，P＝0.59）、0.12（-1.59，1.82，P＝0.89）、-0.54（-1.41，0.33，P=0.23）。结论：特利加压素与白蛋白对预防PPCD的治疗效果相近，可作为替代白蛋白治疗的新选择。
[Abstract]:Objective: to evaluate the effect of trivasopressin on preventing post-paracentesis circulatory function PPCDs after abdominal puncture. Methods: the database of PubMedus EMbase Cochrane Library and China KnowledgeNet were used. To retrieve the literature published before October 2013 on the use and comparison of trivasopressin and albumin in the prevention of PPCD in cirrhotic patients with massive ascites after massive peritoneal puncture. Meta analysis was performed with RevMan5.2.5 software. Results: the mean arterial pressure, plasma aldosterone concentration, serum creatinine concentration and serum creatinine concentration in patients with LVP were compared with those in albumin group. There was no statistical difference in serum sodium concentration and body weight. The weighted mean value of mean difference and confidence interval (95% confidence interval) were 0.22 ~ 2. 02% -2. 45% -2. 41 ~ 18. 26 ~ 183.44P0. 982.02- 5. 409.4 P0. 59 ~ 0. 59 and 0. 89 ~ 0. 54 ~ 0. 54 ~ 1. 41 ~ 1. 31 ~ 0. 33P0. 23 respectively. Conclusion: the therapeutic effect of trivasopressin and albumin on the prevention of PPCD is similar, and it can be used as a new alternative to albumin therapy.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R575.2

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