含阿莫西林、呋喃唑酮四联疗法补救治疗老年幽门螺旋杆菌感染的效果

发布时间：2018-02-21 14:11

本文关键词： 幽门螺旋杆菌阿莫西林呋喃唑酮　出处：《中国老年学杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的探讨含阿莫西林、呋喃唑酮四联疗法补救治疗老年幽门螺旋杆菌感染的效果及安全性。方法前瞻性选取2011年1月至2015年6月因幽门螺旋杆菌根除治疗失败到本院就诊、根据病情需要接受含阿莫西林、呋喃唑酮四联疗法补救根除治疗的老年患者。给予兰索拉唑30 mg,阿莫西林1 000 mg,呋喃唑酮100 mg,胶体果胶铋200 mg,2次/d,早晚口服,疗程14 d。均于治疗开始后7、14 d及治疗结束4 w后进行随诊,详细记录患者不良反应和症状情况。疗程结束4 w后采用13C-尿素呼气试验检测幽门螺旋杆菌根除情况。结果 117例入选患者中3例由于严重不良反应停药,114例完成治疗,107例成功根除幽门螺旋杆菌,意向性和符合方案分析,根除率分别为93.86%和91.45%;不良反应发生率18.42%。女性患者四联疗法补救治疗幽门螺旋杆菌感染成功率明显高于男性(P0.05);日常无饮酒习惯的患者补救治疗成功率明显高于有饮酒习惯者(P0.05)。根除幽门螺旋杆菌失败的患者以往平均治疗次数明显高于全组平均治疗次数(P0.05);合并其他疾病的患者不良反应发生率明显高于无合并疾病者(P0.05)。结论含阿莫西林、呋喃唑酮四联疗法14 d疗程幽门螺旋杆菌根除率较高(90%),不良反应发生率在可接受范围内;该方案治疗期间应重视男性有饮酒习惯、多次根除治疗失败、合并其他疾病的患者。
[Abstract]:Objective to investigate the efficacy and safety of quadruple therapy with amoxicillin and furazolidone in the treatment of Helicobacter pylori infection in the elderly. Elderly patients who received remedial eradication therapy with amoxicillin and furazolidone according to their condition, were given lansoprazole 30 mg, amoxicillin 1 000 mg, furazolidone 100 mg, colloidal bismuth pectin 200 mg / d, orally orally in the morning and evening, The course of treatment was 14 days. All patients were followed up at 714 days after treatment and 4 weeks after treatment. After 4 weeks of treatment, 13C-urea breath test was used to detect the eradication of Helicobacter pylori. Results among 117 patients, 3 patients stopped taking drugs because of severe adverse reactions. 107 cases of Helicobacter pylori were successfully eradicated. Analysis of intentionality and conformity, The rates of eradication were 93.86% and 91.45, respectively. The incidence of adverse reactions was 18.42. The success rate of treatment of Helicobacter pylori infection in female patients was significantly higher than that in men (P 0.05), and the success rate in patients with daily drinking habits was significantly higher than that in patients with drinking. The average times of treatment in patients with failed eradication of Helicobacter pylori in the past were significantly higher than those in the whole group, and the incidence of adverse reactions in patients with other diseases was significantly higher than that in patients without other diseases. The eradication rate of Helicobacter pylori was higher than that of furazolidone quadruple therapy for 14 days, and the incidence of adverse reactions was within the acceptable range. During the course of the treatment, attention should be paid to the men who had the habit of drinking, the failure of multiple eradication treatments and the patients with other diseases.
【作者单位】：南京工业大学;
【分类号】：R573.1

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