恩替卡韦与拉米夫定治疗e抗原阳性慢性乙型病毒性肝炎的临床研究

发布时间：2018-02-22 03:24

本文关键词： 恩替卡韦拉米夫定 HBeAg阳性慢性乙型肝炎 HBeAg血清学转换　出处：《中国临床药理学杂志》2015年14期 　论文类型：期刊论文

【摘要】：目的评价恩替卡韦治疗e抗原阳性慢性乙型病毒性肝炎的临床疗效和安全性。方法 80例乙型肝炎e抗原(HBeAg)阳性慢性乙肝患者随机分为恩替卡韦组(试验组)和拉米夫定组(对照组),各40例。试验组口服恩替卡韦片500 mg·d-1,对照组口服拉米夫定片100 mg·d-1,疗程均为48周,比较2组患者在8,12,24,36,48周时谷丙转氨酶(ALT)复常率、乙肝病毒DNA(HBV-DNA)低于下限率和HBe Ag血清学转换率,且观察治疗期间2组患者的不良反应。结果在第8,12周时,试验组谷丙转氨酶复常率为47.50%,65.00%,明显高于对照组的25.00%,42.50%(P0.05);试验组在各时间点HBV-DNA低于下限率均明显高于对照组(P0.05);36,48周时,试验组HBe Ag血清学转换率为32.50%,35.00%,明显高于对照组的12.50%,15.00%(P0.05)。2组不良反应发生率差异无统计学意义(P0.05)。结论恩替卡韦治疗HBe Ag阳性慢性乙肝疗效好,不良反应发生率低。
[Abstract]:Objective to evaluate the efficacy and safety of entecavir in treatment of e antigen positive chronic hepatitis B. Methods 80 cases of hepatitis B e antigen (HBeAg) positive chronic hepatitis B patients were randomly divided into entecavir group (experimental group) and lamivudine group (control group), 40 cases in each test group was treated with entecavir. Entecavir tablets 500 mg - D-1, control group was treated with the Lamivudine Tablets 100 mg - D-1, were treated for 48 weeks were compared between the 2 groups in 8,12,24,36,48 weeks Shigu alanine aminotransferase (ALT) normalization rate, DNA of hepatitis B virus (HBV-DNA) is lower than the lower limit rate and HBe rate of Ag seroconversion, and observe the adverse reactions during treatment in 2 groups the results. In 8,12 weeks, the experimental group ALT normalization rate was 47.50%, 65%, significantly higher than the control group 25%, 42.50% (P0.05); the experimental group at each time point HBV-DNA below the lower limit rate were significantly higher than the control group (P0.05); 36,48 weeks, group HBe Ag blood test The conversion rate of Qing school was 32.50%, 35%, which was significantly higher than 12.50% of the control group. There was no significant difference in the incidence of adverse reactions in 15% (P0.05).2 group (P0.05). Conclusion entecavir is effective in treating HBe Ag positive chronic hepatitis B, and the incidence of adverse reactions is low.

【作者单位】：杭州市中医院感染科;
【分类号】：R512.62

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