感染HBV或HCV肝病患者血清半胱氨酸蛋白酶抑制剂的改变分析

发布时间：2018-02-25 09:50

本文关键词： 甲型肝炎病毒丙型肝炎病毒感染血清半胱氨酸蛋白酶抑制剂C 肝病抑制剂　出处：《中华医院感染学杂志》2016年09期 　论文类型：期刊论文

【摘要】：目的探讨感染甲型肝炎病毒(HBV)或丙型肝炎病毒(HCV)的肝病患者血清半胱氨酸蛋白酶抑制剂的改变,为HBV或HCV感染患者的检查和治疗提供依据。方法回顾性选择2013年5月-2015年8月住院治疗的98例肝病患者进行研究,将临床确诊感染HBV或HCV的52例患者设为观察组,46例肝脏良性病变患者设为对照组,采集两组患者痰液标本进行病原菌培养,分别应用胶乳增强免疫透射比浊法,检测两组患者血清半胱氨酸蛋白酶抑制剂C(CystatinC)和金属蛋白酶组织抑制剂(TIMPs)浓度,再分别检测两组患者的血谷丙转氨酶(ALT)、谷草转氨酶(AST)、血清肌酐(SCr)、尿素(Urea)及尿肌酐(UCr)、水平,对比分析上述检测结果。结果两组患者共检出病原菌149株,其中观察组102株、对照组47株;两组患者均以革兰阴性菌为主,分别占42.28%和19.46%,其中以大肠埃希菌最多,分别占20.81%和12.08%;观察组患者CystatinC和基质金属蛋白酶的组织抑制剂-1(TIMP1)、基质金属蛋白酶的组织抑制剂-2(TIMP2)浓度明显高于对照组;观察组患者ALT、AST、SCr和Urea水平显著高于对照组;以上差异均有统计学意义(P0.05)。结论感染HBV或HCV的肝病患者血清半胱氨酸蛋白酶抑制剂水平随着感染加重而升高,CystatinC等是监测肝病患者肝功能损害的重要指标。
[Abstract]:Objective to investigate the changes of serum cysteine protease inhibitors in patients with liver diseases infected with hepatitis A virus (HBV) or hepatitis C virus (HCV). Methods 98 patients with liver disease who were hospitalized from May 2013 to August 2015 were studied retrospectively. Fifty-two patients with HBV or HCV infection were divided into two groups: control group (n = 46) and control group (n = 46). Sputum samples from two groups were collected for pathogen culture, and latex enhanced immunoturbidimetry was used respectively. Serum levels of serum cysteine protease inhibitor (Cy cystatin C) and tissue inhibitor of metalloproteinase (TIMP) were measured, and the levels of serum alanine aminotransferase (alt), aspartate aminotransferase (AST), serum creatinine (SCR), urea (Urea) and urinary creatinine (UCr) were measured. Results A total of 149 strains of pathogenic bacteria were detected in the two groups, 102 in the observation group and 47 in the control group, and the two groups were mainly Gram-negative bacteria, accounting for 42.28% and 19.46 respectively, among which Escherichia coli was the most common. The tissue inhibitor of CystatinC and matrix metalloproteinase (TIMP 1) and tissue inhibitor of matrix metalloproteinase (TIMP 2) in the observation group were significantly higher than those in the control group, while the levels of alt ASTT SCR and Urea in the observation group were significantly higher than those in the control group. Conclusion the serum cysteine protease inhibitor level in patients with liver disease infected with HBV or HCV increases with the exacerbation of infection. Cystatin C is an important index for monitoring liver function damage in patients with liver disease.
【作者单位】：胜利石油管理局河口医院检验科;胜利石油管理局胜北医院骨外科;胜利石油管理局河口医院妇产科;胜利石油管理局河口医院中医科;胜利石油管理局河口医院放射科;
【基金】：山东省科技厅研究基金资助项目(201324139)
【分类号】：R512.6;R446.6

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