新疆地区隐源性肝硬化的临床特征及可能病因分析

发布时间：2018-02-25 15:11

本文关键词： 隐源性肝硬化病因原发性肝癌高血压糖尿病　出处：《新疆医科大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：通过分析新疆地区隐源性硬化患者的临床特征,探讨在乙型肝炎病毒(Hepatitis B virus,HBV)高流行区域隐源性肝硬化的可能病因。方法：回顾性分析2001年1月-2009年1月新疆医科大学第一附属医院241例符合隐源性肝硬化诊断标准的住院肝硬化病例资料,其中包括隐源性肝硬化患者222例,隐源性肝硬化伴原发性肝细胞癌患者19例,对其性别、年龄、民族、合并高血压、糖尿病等代谢伴发情况进行研究分析。结果：4023例肝硬化患者中有241例符合隐源性肝硬化的诊断标准,占据总体肝硬化患者的5.99%,在241例患者中有98例(40.66%)合并糖尿病,55例合并高血压(22.82%),其中222例为单纯隐源性肝硬化(平均年龄54.86岁±16.09岁,44%为男性),隐源性肝硬合并肝癌的患者共19例,肝癌的发生率为7.88%(平均年龄67.42岁±7.03岁,47%为男性),其中隐源性肝硬化组和隐源性肝硬化合并肝癌组的糖尿病发病率分别为40%和57%,高血压发病率分别为20%和58%。单因素分析结果显示,单纯隐源性肝硬化和隐源性肝硬化合并肝癌患者在年龄和高血压方面有显著性差异(t=-6.47,P0.001)和(t=13.8,P0.001),收缩压和舒张压在两组中也有显著性差异(t=-3.63,P0.001)和(t=-3.42,P0.001),多因素回归分析显示年龄、高血压是隐源性肝硬化发展为肝癌的独立危险因素(OR=1.086,95%CI:1.03-1.14,P0.001; OR=5.4,95%CI:2.05-14.23,P0.001)。结论：我们的研究显示,本组隐源性肝硬化合并较高的2型糖尿病和高血压代谢综合征指征,符合非酒精性脂肪肝病的临床特征,提示作为HBV较高流行的新疆地区隐源性肝硬化与非酒精脂肪性肝病具有相关的可能性大。
[Abstract]:Objective: to analyze the clinical characteristics of patients with cryptogenic sclerosis in Xinjiang. To explore the possible etiology of cryptogenic cirrhosis in the high prevalence area of hepatitis B virus hepatitis B. methods: from January 2001 to January 2009, 241 cases of cryptogenic cirrhosis in the first affiliated Hospital of Xinjiang Medical University were analyzed retrospectively. Accurate data of inpatient liver cirrhosis cases, These included 222 patients with cryptogenic cirrhosis and 19 patients with primary hepatocellular carcinoma. Results 241 out of 4023 patients with liver cirrhosis met the diagnostic criteria of cryptogenic cirrhosis. Of the total patients with liver cirrhosis, 5.99m, 98 out of 241 patients (40.66) were associated with diabetes mellitus and 55 patients with hypertension, 222 patients were simple cryptogenic cirrhosis (mean age was 54.86 years 卤16.09 years old, 44% were male patients, 19 cases of cryptogenic hepatocirrhosis complicated with liver cancer), and there were 19 cases of cryptogenic hepatocirrhosis complicated with liver cancer, among which 222 cases were simple cryptogenic cirrhosis (mean age: 54.86 years 卤16.09 years old, 44%). The incidence of liver cancer was 7.88% (mean age: 67.42 卤7.03 years old, 47%). The incidence of diabetes mellitus and hypertension were 40% and 57 in the patients with cryptogenic cirrhosis and hepatocellular carcinoma, respectively. The results of univariate analysis showed that the incidence of diabetes mellitus and hypertension were 20% and 58.The results of univariate analysis showed that. There were significant differences in age and hypertension between patients with simple cryptogenic cirrhosis and cryptogenic cirrhosis with liver cancer. There were significant differences in systolic blood pressure and diastolic blood pressure between the two groups in age and hypertension. Multivariate regression analysis showed that age was significantly higher than that of diastolic blood pressure. Hypertension is an independent risk factor for the development of cryptogenic liver cirrhosis into hepatocellular carcinoma (CI: 1.03-1.14 P0.001). Conclusion: our study shows that cryptogenic cirrhosis is associated with higher type 2 diabetes mellitus and hypertension metabolic syndrome. In accordance with the clinical characteristics of non-alcoholic fatty liver disease, it is suggested that cryptogenic cirrhosis and non-alcoholic fatty liver disease are likely to be related to the prevalence of HBV in Xinjiang.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R575.2

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