特利加压素联合白蛋白治疗Ⅰ型肝肾综合征疗效的荟萃分析

发布时间：2018-02-25 22:17

本文关键词： 特利加压素白蛋白肝肾综合征荟萃分析　出处：《世界华人消化杂志》2016年36期 　论文类型：期刊论文

【摘要】：目的收集中英文相关随机对照试验(randomized controlled trial,RCT)的研究结果进行Meta分析,对特利加压素联合白蛋白对肝肾综合征(hepatorenal syndrome,HRS)的疗效进行评价.方法采用Cochrane系统评价方法,检索PubMed,The Cochrane Library,Web of Science and LILACS,Medline,EMBASE,中国生物医学文献数据库,维普中文科技期刊数据库,中国CNKI学术总库,万方数据资源系统等数据库,检索截止2016-07以前的所有公开发表文献.结果 6篇RCT共542例患者纳入本荟萃分析,特利加压素联合白蛋白在HRS治疗中较单独应用白蛋白可明显提高HRS缓解率(OR=5.25,95%CI:2.77-6.52);提高生存率(OR=2.33,95%CI:1.11-4.88);同时可降低血肌酐水平,升高平均动脉压,但对尿量的影响无明显差异.其不良反应包括由于体循环充血及外周循环收缩导致的症状,如腹痛、肢体末端紫绀等,但无致死性不良反应报道.结论特利加压素联合白蛋白对改善HRS较单独应用白蛋白有较好的作用,可提高临床缓解率和生存率,且无明显严重不良反应,安全性好.
[Abstract]:Objective to collect the results of randomized controlled trialoma (rct) and evaluate the efficacy of trivasopressin combined with albumin in the treatment of hepatorenal syndrome (HRS). Methods Cochrane system was used to evaluate the efficacy of RCT in the treatment of hepatorenal syndrome. To search the Cochrane Library of Science and Lilac Medline, China Biomedical Literature Database, Weipu Chinese Science and Technology Journal Database, China CNKI academic Master, Wanfang data Resource system, etc. Results 542 patients with 6 RCT were included in this meta-analysis. Compared with albumin alone, trivasopressin combined with albumin can significantly improve the remission rate of HRS and increase the survival rate of CI: 2.77-6.52%, increase the survival rate by 2.3395% CI: 1.11-4.88, and decrease the level of serum creatinine and increase the mean arterial pressure. However, there was no significant difference in urine volume. Adverse reactions included symptoms caused by systemic congestion and peripheral circulation contraction, such as abdominal pain, cyanosis at the extremities, etc. Conclusion Trevasopressin combined with albumin has a better effect on the improvement of HRS than that of albumin alone. It can improve the clinical remission rate and survival rate. There is no significant serious adverse reaction and the safety is good.
【作者单位】：河南科技大学临床医学院;河南科技大学第一附属医院消化内科;河南科技大学第一附属医院胃镜室;
【分类号】：R575;R692

【相似文献】