ABO血型与幽门螺杆菌感染风险的meta分析

发布时间：2018-02-26 08:40

本文关键词： ABO血型系统幽门螺杆菌感染风险 meta分析　出处：《第二军医大学学报》2016年11期 　论文类型：期刊论文

【摘要】：目的通过meta分析探讨ABO血型系统与幽门螺杆菌感染发生的关系。方法以PubMed、EMBASE、CNKI等作为文献来源数据库,并追溯相关参考文献和引文,进行全面、系统的文献检索。收集ABO血型系统与幽门螺杆菌感染关系的文献研究,根据纳入和排除标准,由2名研究者独立筛选文献、提取数据并进行文献质量评价,采用Review Manager5.0、Stata 11.0软件进行meta分析、敏感性分析及发表偏倚的评估。以比值比(OR)作为评估ABO血型与幽门螺杆菌感染关系的指标,采用Egger法及漏斗图评价发表偏倚。结果本研究共纳入文献31篇。敏感性分析的结果显示Lin等的研究明显影响了系统分析的结果,剔除该研究后,重新合并OR值。Meta分析结果表明:ABO血型与幽门螺杆菌感染发生无关(血型A:OR=0.98,95%CI0.84~1.15,P=0.82;血型B:OR=0.93,95%CI 0.84~1.03,P=0.15;血型O:OR=1.10,95%CI0.93~1.29,P=0.26;血型AB:OR=0.84,95%CI0.67~1.06,P=0.14)。Egger法计算结果显示不存在发表偏倚,而漏斗图则显示存在潜在发表偏倚。亚组分析结果也显示ABO血型与幽门螺杆菌感染发生无关。结论 ABO血型与幽门螺杆菌感染的发生无关。
[Abstract]:Objective to investigate the relationship between ABO blood group system and Helicobacter pylori infection by meta. Systematic literature retrieval. The relationship between ABO blood group system and Helicobacter pylori infection was collected. According to the inclusion and exclusion criteria, two researchers independently screened the literature, extracted the data and evaluated the quality of the literature. Review Manager 5.0 / Stata 11.0 software was used for meta analysis, sensitivity analysis and publication bias evaluation. The ratio ratio was used to evaluate the relationship between ABO blood group and Helicobacter pylori infection. Results 31 papers were included in this study. The results of sensitivity analysis showed that the results of Lin et al significantly affected the results of systematic analysis. The recombined OR value. Meta-analysis showed that there was no correlation between the ABO blood group and the infection of Helicobacter pylori (blood type A: OR0.98895 CI0.84 1.15P0.82; blood group B: OR0.9395CI0.84C0.841.03P0.15; blood group O: OR1.1095CI0.931.29P0.26; ABO: 0.8495CI0.671.06Pn0.14.Egger calculation results showed that there was no publication bias. The results of subgroup analysis also showed that ABO blood group had no relationship with Helicobacter pylori infection. Conclusion ABO blood group is not related to the occurrence of Helicobacter pylori infection.
【作者单位】：温州医科大学附属第一医院外科实验室;温州医科大学附属第一医院外科;
【基金】：国家级大学生创新创业训练计划项目(201510343012) 浙江省大学生科技创新活动计划(新苗人才计划)项目(2016R413050)~~
【分类号】：R573

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