肝右静脉与下腔静脉位置对布-加综合征产生机制的影响

发布时间：2018-02-26 09:14

本文关键词： 布-加综合征下腔静脉肝右静脉数值模拟血流动力学　出处：《医用生物力学》2015年05期 　论文类型：期刊论文

【摘要】：目的探讨不同肝右静脉与下腔静脉夹角变化对布-加综合征患者下腔静脉隔膜发生机制的影响。方法运用Mimics软件对临床磁共振成像血管造影下腔静脉和主要肝静脉图像进行三维实体模型重建,测得正常模型下腔静脉与肝右静脉夹角为56°。在保持模型基本结构不变基础上,分别构建肝右静脉与下腔静脉夹角为30°和120°的模型,并数值模拟计算3个模型的壁面剪切力、壁面压强、速度分布。结果 3个模型壁面压强、壁面剪切力差异显著。与正常人56°模型相比,30°模型有较高的壁面压强和较低的血液流速,120°模型有较低的壁面剪切力和血液流速,并伴随有涡流的出现,这些血流动力学因素的改变更易于血栓的形成。56°模型血管内血流流速最快。结论对下腔静脉与肝右静脉血液流场的数值模拟有助于了解布-加综合征的发病机制,提高下腔静脉阻塞隔膜形成风险的预测,为治疗提供理论依据。
[Abstract]:Objective to investigate the effect of different angles between right hepatic vein and inferior vena cava on the pathogenesis of inferior vena cava septum in patients with Budd-Chiari syndrome. Methods Mimics software was used to evaluate the relationship between inferior vena cava and main hepatic statics in patients with Budd-Chiari syndrome. The pulse image is reconstructed by 3D solid model. The angle between the inferior vena cava and the right hepatic vein was 56 掳. On the basis of keeping the basic structure of the model unchanged, the models with 30 掳and 120 掳angles of the right hepatic vein and the inferior vena cava were constructed, and the wall shear forces of the three models were numerically simulated. Results the wall pressure and velocity distribution of the three models, Compared with the normal 56 掳model, the 30 掳model has higher wall pressure and lower blood velocity (120 掳) with lower wall shear force and blood velocity, accompanied by the appearance of eddy current. The changes of these hemodynamic factors are more likely to cause thrombosis. 56 掳model of intravascular blood flow velocity is the fastest. Conclusion the numerical simulation of blood flow field of inferior vena cava and right hepatic vein is helpful to understand the pathogenesis of Budd-Chiari syndrome. To improve the prediction of the risk of septum formation in inferior vena cava occlusion and provide theoretical basis for treatment.
【作者单位】：上海理工大学医疗器械与食品学院;复旦大学附属华东医院疼痛科;
【基金】：国家自然科学基金项目(61101174) 上海市科委医学领先项目(12401907700) 微创励志创新基金
【分类号】：R575

【参考文献】