院内二次感染对肝硬化患者死亡风险水平的影响

发布时间：2018-02-26 15:01

本文关键词： 感染肝硬化死亡率 Logistic回归模型　出处：《吉林大学学报(医学版)》2015年04期 　论文类型：期刊论文

【摘要】：目的:探讨肝硬化患者的死亡率与二次感染之间的关系,阐明二次感染对肝硬化患者死亡风险水平的影响。方法:共纳入103例肝硬化患者,分为初次感染组(78例)和二次感染组(25例),比较2组患者的基本特征、终末期肝病模型(MELD)评分、血清白蛋白水平、感染的微生物和30d内的死亡率等,分析各部位感染发生率的变化,并通过多因素Logistic回归模型分析肝硬化患者死亡的危险因素。结果:与初次感染组比较,二次感染组患者死亡率明显增加(P0.05),肺炎和艰难梭状芽孢杆菌相关性肠炎(CDAD)的发生率明显增加(P0.05)。多因素Logistic回归模型分析,发生二次感染(OR=4.582,P=0.000 2)、高MELD评分(OR=1.293,P0.000 1)和低血清白蛋白(OR=0.487,P=0.038 7)是肝硬化患者死亡的独立危险因素。结论:院内二次感染能显著增加肝硬化患者死亡风险水平。
[Abstract]:Objective: to investigate the relationship between mortality and secondary infection in patients with liver cirrhosis, and to elucidate the influence of secondary infection on the risk of death in patients with cirrhosis. Methods: 103 patients with liver cirrhosis were included in this study. Two groups were divided into primary infection group (n = 78) and secondary infection group (n = 25). The basic characteristics of the two groups were compared, the end stage liver disease model (MELDD) score, serum albumin level, infected microorganism and mortality within 30 days were compared. The risk factors of death in patients with liver cirrhosis were analyzed by multivariate Logistic regression model. In the secondary infection group, the mortality rate was significantly increased (P 0.05), and the incidence of pneumonia and Clostridium difficulty associated enteritis was significantly increased (P 0.05). Multivariate Logistic regression model analysis was used. The risk factors of death in patients with liver cirrhosis were the secondary infection (4.582%), high MELD score (1.293 P 0.000 1) and low serum albumin (0.487) P (0.038 7). Conclusion: secondary nosocomial infection can significantly increase the risk of death in patients with liver cirrhosis.
【作者单位】：兰州大学第一医院感染科;兰州大学第一临床医学院;
【基金】：甘肃省科技厅青年科技基金资助课题(145RJYA247)
【分类号】：R575.2

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