维生素D受体和脂联素基因多态性和非酒精性脂肪肝易感性临床关系研究

发布时间：2018-03-01 05:34

本文关键词： 受体骨化三醇脂联素基因多态性非酒精性脂肪肝易感性　出处：《重庆医学》2017年12期 　论文类型：期刊论文

【摘要】：目的探讨分析维生素D受体和脂联素基因多态性和非酒精性脂肪肝易感性临床关系。方法选取102例非酒精性脂肪肝患者作为观察组,另选取100例健康志愿者作为对照组。对维生素D受体和脂联素基因多态性进行检测,比较两组维生素D受体和脂联素基因型分布和等位基因频率,并分析其和非酒精性脂肪肝易感性临床关系。结果观察组维生素D受体BsmI位点、脂联素45和276位点基因型分布情况和对照组比较差异均有统计学意义(P0.05);观察组维生素D受体BsmI位点B等位基因频率远远低于对照组,而前者维生素D受体45-T和276-G等位基因频率均远远高于后者,两组间各项数据比较差异均有统计学意义(P0.05);多因素非条件Logistic回归分析显示,维生素D受体:bb基因型、脂联素45位点:TT基因型以及丙氨酸转氨酶(ALT)、三酰甘油(TG)、合并高血压史、胰岛素指数(HOMA-IR)均为影响非酒精性脂肪肝患者的独立危险因素。结论维生素D受体和脂联素不同位点基因型分布在非酒精性脂肪肝患者中存在明显异常,二者和其易感性存在紧密关联。
[Abstract]:Objective to investigate the vitamin D receptor and adiponectin gene polymorphisms and susceptibility to non alcoholic fatty liver disease in clinical. Methods 102 cases of nonalcoholic fatty liver disease patients as the observation group, another 100 cases of healthy volunteers as control group. To detect the vitamin D receptor and adiponectin gene polymorphism, vitamin D receptor and compared between the two groups adiponectin genotype distribution and allele frequency, and its analysis and susceptibility to non alcoholic fatty liver disease. The clinical results in the observation group, vitamin D receptor BsmI 45 and 276 loci, adiponectin genotype distribution and control group were statistically significant (P0.05); observation group of vitamin D receptor BsmI B allele the gene frequency is much lower than the control group, and the vitamin D receptor 45-T and 276-G allele frequencies were much higher than that of the latter, between the two groups compared with statistical data The significance (P0.05); non conditional Logistic regression analysis showed that the vitamin D receptor: BB genotype, adiponectin 45 loci: TT genotype and alanine aminotransferase (ALT), triglyceride (TG), three with a history of high blood pressure, insulin index (HOMA-IR) were the independent risk of patients with nonalcoholic fatty liver conclusion. The vitamin D receptor and adiponectin in different genotype distribution in patients with nonalcoholic fatty liver disease is abnormal, and the susceptibility of two closely related.

【作者单位】：中南大学湘雅三医院消化内科;海南省人民医院消化内科;
【基金】：2014年海南省自然科学基金资助项目(814310)
【分类号】：R575.5

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