急性胰腺炎患者血清微管相关蛋白1轻链3水平变化及意义

发布时间：2018-03-01 06:05

  本文关键词： 急性胰腺炎 自噬 微管相关蛋白轻链　出处：《山东医药》2017年30期 　论文类型：期刊论文

【摘要】：目的观察急性胰腺炎(AP)患者血清微管相关蛋白1轻链3(MAP1-LC3)水平变化,探讨其临床意义。方法选择轻型AP患者(MAP组)31例和重症AP患者(SAP组)31例,于发病24 h内抽取血清样本,另选择31例健康者作为对照组。检测血清淀粉酶(Ams)、MAP1-LC3水平,对AP患者的腹部CT进行评分。结果与对照组比较,MAP组、SAP组血清Ams、MAP1-LC3水平及腹部CT评分均升高(P均0.05),其中SAP组较MAP组上述指标升高(P均0.05);血清MAP1-LC3水平与腹部CT评分呈正相关(r=0.977,P0.01),与Ams呈正相关。结论 AP患者发病早期血清MAP1-LC3水平明显升高,并与AP的病情严重程度呈正相关关系;血清MAP1-LC3可能是早期预测AP严重程度的有效标记物。
[Abstract]:Objective to observe the changes of serum microtubule associated protein 1 light chain MAP1-LC3 levels in patients with acute pancreatitis (AP) and to explore its clinical significance. Methods 31 patients with mild AP and 31 patients with SAP with severe AP were selected to collect serum samples within 24 hours after onset of acute pancreatitis. In addition, 31 healthy subjects were selected as control group. The serum amylase amylase MAP1-LC3 levels were measured. Results compared with the control group, the levels of serum amsoma-MAP1-LC3 and abdominal CT scores in map group were significantly higher than those in MAP group (P < 0.05), and the serum MAP1-LC3 level and abdominal CT score were higher in SAP group than those in MAP group (P < 0.05). There was a positive correlation between the positive correlation and Ams. Conclusion the serum MAP1-LC3 level of AP patients increased significantly in the early stage of AP. Serum MAP1-LC3 may be an effective marker for early prediction of AP severity.
【作者单位】： 武汉市普爱医院;
【分类号】：R576
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本文编号：1550703