非甾体抗炎药对伴有幽门螺杆菌感染风湿病患者胃肠激素及消化道的影响

发布时间：2018-03-02 04:12

本文关键词： 非甾体抗炎药幽门螺杆菌感染风湿病胃肠激素不良消化道情况　出处：《中华医院感染学杂志》2017年16期 　论文类型：期刊论文

【摘要】：目的研究及观察非甾体抗炎药对伴有幽门螺杆菌感染风湿病患者胃肠激素及不良消化道情况的影响,以了解幽门螺杆菌感染对该类患者消化系统的危害。方法选取2015年5月-2016年4月医院诊治的38例伴有幽门螺杆菌感染的风湿病患者为观察组,选取同时间段的35例无幽门螺杆菌感染的风湿病患者为对照组,对两组患者不良消化道情况发生率,治疗前后不同时间的血清胃肠激素水平进行前瞻性研究及比较。结果观察组十二指肠溃疡、胃溃疡及糜烂性胃炎发生率为18.42%、13.16%、13.16%,均高于对照组的2.86%、0、0(P0.05);治疗前两组患者的餐前及餐后血清胃肠激素水平均无明显差异,治疗后不同时间观察组的餐前及餐后血清胃肠激素GAS、MTL、VIP及CKK水平分别为(102.52±10.47)ng/L、(229.89±21.65)ng/L、(120.75±11.01)ng/L、(14.88±1.49)pg/ml,(110.23±11.35)ng/L、(268.48±25.95)ng/L、(137.37±12.54)ng/L、(12.58±1.32)pg/ml;(108.69±12.56)ng/L、(248.58±22.97)ng/L、(130.17±12.84)ng/L、(16.32±1.68)pg/ml,(123.56±14.68)ng/L、(283.93±26.75)ng/L、(140.77±13.92)ng/L、(14.93±1.52)pg/ml,均高于对照组(P0.05)。结论:非甾体抗炎药物对伴有幽门螺杆菌感染风湿病患者胃肠激素及不良消化道情况的影响较大,应对该类患者进行积极的抗幽门螺杆菌治疗。
[Abstract]:Objective to study and observe the effects of non-steroidal anti-inflammatory drugs on gastrointestinal hormones and adverse gastrointestinal conditions in patients with rheumatism associated with Helicobacter pylori infection. To understand the harm of Helicobacter pylori infection to the digestive system of the patients, 38 cases of rheumatism with Helicobacter pylori infection were selected as observation group from May 2015 to April 2016. Thirty-five patients with rheumatism without Helicobacter pylori infection were selected as control group in the same period. The serum levels of gastrointestinal hormones at different time before and after treatment were prospectively studied and compared. The incidence of gastric ulcer and erosive gastritis was 18.42 and 13.16, which was higher than that of the control group (2.86), P 0.050.There was no significant difference in serum gastrointestinal hormone levels before and after meal between the two groups. At different time after treatment, the levels of GAS-MTLN VIP and CKK in preprandial and postprandial serum in the observation group were 102.52 卤10.47ng / L, respectively: 108.69 卤10.47ngL / L = 229.89 卤21.65ngL / L = 120.75 卤11.01ngL / L = 14.88 卤1.49pgml / L 110.23 卤11.35ngL / L = 268.48 卤25.95ngL / L 137.37 卤12.54ngL / L = 12.58 卤1.32pgml / L = 108.69 卤12.56ngml / L + 248.58 卤22.56ngL / L = 138.58 卤1.84ngL 16.32 卤1.68ng / L 16.32 卤1.68ng123.68ng / L 26.993 卤13.993 卤13.593 卤1.593 卤1.593 卤1.56ng / g respectively. The influence of digestive tract condition is greater, Active anti-Helicobacter pylori treatment should be performed in these patients.
【作者单位】：郑州大学附属南阳市中心医院肾内科;郑州大学附属南阳市中心医院心内科;
【分类号】：R57;R593.2

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