3种治疗方案根除幽门螺杆菌的成本-效果分析

发布时间：2018-03-02 04:35

本文关键词： 幽门螺杆菌三联疗法左氧氟沙星序贯疗法成本-效果分析　出处：《中国药房》2015年11期 　论文类型：期刊论文

【摘要】：目的:评价3种治疗方案根除幽门螺杆菌的成本与效果。方法:将128例消化性溃疡或慢性胃炎患者随机分为3组。A组41例,给予泮托拉唑(40 mg,bid)+阿莫西林(1 g,bid)+克拉霉素(0.5 g,bid);B组44例,给予泮托拉唑(40 mg,bid)+阿莫西林(1 g,bid)+左氧氟沙星(0.2 g,bid);C组43例,前5日给予泮托拉唑(40 mg,bid)+阿莫西林(1 g,bid),后5日改为泮托拉唑(40 mg,bid)+左氧氟沙星(0.2 g,bid)+克拉霉素(0.5 g,bid)。疗程均为10 d。观察3组的临床疗效,并进行成本-效果分析。结果:B组的按方案治疗(PP)根除率和意向治疗(ITT)根除率与C组比较差异无统计学意义(P0.05),但与A组比较差异有统计学意义(P0.05);B组PP根除率和ITT根除率的成本-效果比及增量成本-效果比均优于A组和C组。结论:从药物经济学角度来看,B方案为最经济、有效的治疗幽门螺杆菌方案,可以推广;A方案最差,不应再作为一线治疗方案考虑。
[Abstract]:Objective: to evaluate the cost and effectiveness of three treatments for the eradication of Helicobacter pylori. Methods: 128 patients with peptic ulcer or chronic gastritis were randomly divided into three groups: group A (n = 41), group A (n = 41), and group A (n = 41). N = 44 patients in group B with clarithromycin 0.5 g of carramycin and 40 mg / g bid with pam Tora (40 mg / g bid), 43 cases in group C (n = 43) were treated with levofloxacin (0.2 mg / g bidbidine) and control group (n = 43), group B (n = 44), group B (n = 44), group B (n = 44), group B (n = 44), group B: n = 40 (n = 40). Before 5th, pam Tora zolazolone 40 mg bid) amoxicillin 1 g bid, then on 5th was changed to pam Tora azolium 40 mg bid) levofloxacin 0. 2 mg bid) clarithromycin 0. 5 g bidbid.the course of treatment was 10 days. The clinical efficacy of the three groups was observed. Results there was no significant difference in eradication rate between group B and group C (P 0.05), but there was a significant difference between group A and group A in the eradication rate of PP and ITT in group B. Cost-effectiveness ratio and incremental cost-effect ratio of eradication rate were better than those of group A and C. conclusion: from the point of view of pharmacoeconomics, regimen B is the most economical. An effective regimen for Helicobacter pylori is the worst and should not be considered as a first-line treatment.
【作者单位】：上海交通大学医学院附属第九人民医院药剂科;
【基金】：上海交通大学医学院附属第九人民医院院级基金(No.JY2011B13)
【分类号】：R573.1

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