非酒精性脂肪肝病合并胰岛素抵抗患者血清chemerin和hs-CRP水平的研究

发布时间：2018-03-02 14:07

本文选题：C反应蛋白质　切入点：脂肪类　出处：《重庆医学》2017年02期 　论文类型：期刊论文

【摘要】：目的测定非酒精性脂肪肝病(NAFLD)患者血清中视黄酸受体反应蛋白2(chemerin)、超敏C反应蛋白(hs-CRP)的表达水平,以及胰岛素抵抗指数(HOMA-IR),探讨chemerin在NAFLD发病中的机制。方法将NAFLD患者分为两组,NAFLD组(30例)和NAFLD+IR组(30例);并选择健康体检者30例作为健康对照组。用双抗体夹心酶联免疫吸附法检测血清chemerin,免疫比浊法检测血清hs-CRP,同时测定空腹血糖(FPG)、空腹胰岛素(FINS),并计算胰岛素抵抗指数(HOMA-IR)。结果与健康对照组相比较,NAFLD组患者的血清chemerin和hs-CRP水平明显升高(P0.05)。与健康对照组和NAFLD组比较,NAFLD+IR组患者的血清chemerin和hs-CRP水平也明显升高(P0.05)。血清chemerin水平与hs-CRP、HOMA-IR呈显著正相关。结论 NAFLD患者的血清chemerin水平与hs-CRP、HOMA-IR相关。
[Abstract]:Objective to determine the expression of retinoic acid receptor reactive protein 2 chemerinine, hypersensitive C reactive protein hs-CRPin in the serum of patients with NAF LDD. The mechanism of chemerin in the pathogenesis of NAFLD was studied. Methods the patients with NAFLD were divided into two groups: 30 cases of NAFLD and 30 cases of NAFLD IR, and 30 cases of healthy controls were selected as healthy control group with double antibody sandwich enzyme-linked immunosorbent assay (Elisa). Serum chemerin was detected by immunosorbent assay, serum hs-CRP was detected by immunoturbidimetry, fasting blood glucose and fasting insulin were measured simultaneously, and insulin resistance index (HOMA-IRN) was calculated. Results Serum chemerin and hs-CRP levels in patients with NAFLD were significantly higher than those in healthy controls. The serum chemerin and hs-CRP levels in NAFLD IR group were significantly higher than those in healthy control group and NAFLD group. The serum chemerin level was positively correlated with hs-CRPHOMA-IR. Conclusion the serum chemerin level in NAFLD patients is significantly correlated with hs-CRPPHOMA-IR.
【作者单位】：桂林医学院附属医院老年内科;
【基金】：广西教育厅科研基金资助项目(2013LX075,2013LX077) 广西卫生厅科研基金资助项目(Z2013489) 广西桂林市卫生局科学研究与技术开发计划资助项目(20120121-1-14)
【分类号】：R575

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