四联疗法联合胃复春在慢性萎缩性胃炎治疗中的效果观察

发布时间：2018-03-03 05:13

本文选题：四联疗法　切入点：胃复春　出处：《重庆医学》2017年09期 　论文类型：期刊论文

【摘要】：目的观察四联疗法联合胃复春在慢性萎缩性胃炎(CAG)治疗中的效果。方法选择该院消化内科于2011年1月至2015年1月收治的经病理确诊为CAG并满足1年随访期的患者300例,采用平行随机抽样法将其平均分为A、B、C 3组,每组100例。A组给予饮食干预同时联合避免损害胃黏膜的药物治疗;B组在饮食干预的基础上联合泮托拉唑40mg、阿莫西林1.0g、克拉霉素0.5g、丽珠得乐220mg口服,每天2次,14d根除幽门螺旋杆菌(Hp)联合避免损害胃黏膜的药物治疗;C组在采用四联疗法(同B组)根除Hp后,继续加用胃复春4片饭前30min口服,每天3次,持续治疗1年后,比较各组的胃镜检查疗效、病理复查疗效及Hp转阴情况。结果治疗1年后,3组患者临床症状均有不同程度地好转,复查胃镜结果发现,C组中治愈43例,显效26例,有效17例,无效14例,总有效率为86.00%,明显高于其他两组(P0.05);病理结果发现,C组中治愈37例,显效32例,有效9例,无效22例,总有效率为78.00%,明显高于其他两组(P0.05)。A组中Hp转阴59例(59.00%),B组中Hp转阴81例(81.00%),C组中Hp转阴89例(89.00%),C组明显高于其他两组(P0.05)。结论在CAG患者的临床治疗中联合四联疗法与胃复春治疗,可以有效根除Hp感染,改善临床症状,可以作为CAG治疗的首选治疗方案在临床中推广应用。
[Abstract]:Objective to observe the effect of tetralogy combined with Weifuchun in the treatment of chronic atrophic gastritis (CAG). Methods 300 patients with CAG diagnosed pathologically from January 2011 to January 2015 were selected. The parallel random sampling method was used to divide it into three groups: group A BX and group C. Group A received dietary intervention and combined with drug therapy to avoid gastric mucosal damage. Group B combined with Pam Tora 40 mg, amoxicillin 1.0 g, clarithromycin 0.5 g, Lizhudell 220 mg on the basis of dietary intervention, group B received oral administration of Pam Tora 40 mg, amoxicillin 1.0 g, clarithromycin 0.5 g, and lizudell 220 mg on the basis of dietary intervention. Eradication of Helicobacter pylori (HP) twice a day for 14 days combined with drug therapy to avoid gastric mucosal damage, group C continued to take 4 tablets of Weifuchun orally 30 minutes before meals, 3 times a day, after a year of continuous treatment, after using quadruple therapy (same as group B) to eradicate HP. Results after one year of treatment, the clinical symptoms of the three groups were improved to some extent. According to the results of gastroscopy, 43 cases were cured, 26 cases were markedly effective, and 17 cases were effective. The total effective rate was 86.00%, which was significantly higher than that in the other two groups (P 0.05), and the pathological results showed that 37 cases were cured, 32 cases were effective, 9 cases were effective, 22 cases were ineffective. The total effective rate was 78.00, which was significantly higher than that in the other two groups (P 0.05A group, 59 cases with HP turning negative, group B, 81 cases with HP to negative, 81.00%, group C, 89 cases with HP conversion to negative, group C, 89 cases, P 0.055.Conclusion in the clinical treatment of CAG patients, the combination of Tetratherapy and Weifuchun treatment, 89 cases of HP turn negative to negative is significantly higher than that of the other two groups, P0.055.Conclusion in the clinical treatment of CAG patients, the combination of four combined therapy and Weifu Chun treatment is significantly higher than that of the other two groups. It can effectively eradicate HP infection and improve clinical symptoms. It can be used as the first choice in the treatment of CAG.
【作者单位】：山东省潍坊市第二人民医院消化内科;山东省潍坊市第二人民医院检验科;山东省潍坊市第二人民医院内分泌科;
【基金】：2015年山东省潍坊市科技计划专项资助项目(2015-27号)
【分类号】：R573.32

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