血浆白细胞介素22水平与丙型肝炎患者肝功能及感染结局的相关性

发布时间：2018-03-03 05:03

本文选题：丙型肝炎病毒　切入点：白细胞介素　出处：《中华疾病控制杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的分析江苏地区有偿献血HCV感染人群血浆白细胞介素22(interleukin-22,IL-22)水平与肝功能指标、丙型肝炎病毒(hepatitis C,HCV)载量及HCV感染结局的相关性。方法采用酶联免疫吸附法(enzyme linked immunosorbent,ELISA)检测75例HCV持续感染者、82例HCV自限清除者和90例健康对照者外周血浆中IL-22水平。分析IL-22与肝功能指标及病毒载量的相关性。结果以年龄、性别和体质指数(body mass index,BMI)为协变量,经协方差分析显示,三组间的丙氨酸氨基转移酶(alanine aminotransferase,ALT)和天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)水平差异均有统计学意义(均有P0.05);IL-22水平在三组间的分布无统计学差异(F=0.911,P=0.676);IL-22水平与ALT、AST水平呈正相关,与HCV RNA水平呈负相关,但差异均无统计学意义(均有P0.05)。Logistic回归分析结果显示,HCV病毒载量升高是HCV持续感染者血浆ALT水平升高的独立危险因素(OR=16.926,95%CI:1.695~169.068)。结论 HCV病毒载量与肝功能受损情况密切相关,本研究未发现血浆IL-22水平对肝功能及HCV感染结局有影响,大样本随访研究有助于进一步探讨它们之间的关系。
[Abstract]:Objective to analyze the levels of interleukin-22 interleukin-22 (IL-22) and liver function in paid blood donors infected with HCV in Jiangsu province. Methods Enzyme-linked immunosorbent enzyme (linked) immunosorbent assay (Elisa) was used to detect the level of IL-22 in peripheral plasma of 75 cases of HCV persistent infection and 82 cases of HCV self-clearance and 90 cases of healthy controls. The correlation between IL-22 and liver function index and viral load was analyzed. The gender and body mass index (mass) was covariable, and the analysis of covariance showed that, The levels of alanine aminotransferase (alt) and aspartate aminotransferase (AST) were significantly different among the three groups (P 0.05). There was no significant difference in the distribution of IL-22 between the three groups. There was a negative correlation with the level of HCV RNA. The results of logistic regression analysis showed that the increase of HCV viral load was an independent risk factor for the increase of plasma ALT level in patients with HCV. Conclusion the viral load of HCV is closely related to the damage of liver function. No effect of plasma IL-22 level on liver function and outcome of HCV infection was found in this study.
【作者单位】：南京医科大学第一附属医院医务处;南京医科大学公共卫生学院流行病与卫生统计学系;中国人民解放军南京军区军事医学研究所;南京医科大学第一附属医院感染病科;
【基金】：国家自然科学基金(81502853,81273146) 江苏省自然科学基金(BK20151026,BK20140094) 国家重大科技专项(2013ZX10002005-002-005,2013ZX10004905)
【分类号】：R512.63

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