脾静脉血栓对血流动力学影响的分析及计算流体力学模拟

发布时间：2018-03-05 23:35

本文选题：脾静脉血栓　切入点：肝门静脉系统　出处：《生物医学工程学杂志》2015年01期 　论文类型：期刊论文

【摘要】：本文的目的是分析脾静脉血栓(SVT)对肝门静脉系统血流动力学参数的影响。根据某肝门静脉高压症患者的CT图像和商业软件MIMICS重建了其真实的肝门静脉系统模型,采用彩色多普勒超声法测出了肝门静脉系统内的血流速度,作为模拟的入口边界条件,应用计算流体力学(CFD)方法模拟了肝门静脉系统内血流动力学参数的变化并分析了对生理过程的影响。结果显示:SVT会对肝门静脉系统的血流动力学参数造成严重影响,血液流经SVT时压强降低、流速和壁面剪切力增加,血液流动的阻力增加,门静脉主干内血流速度减缓、压力梯度减小、壁面剪切力的分布更加均匀。SVT会导致对肝脏的供血能力下降,在血栓的周围和门静脉主干内形成新血栓的可能性增加。
[Abstract]:The purpose of this paper is to analyze the effect of splenic vein thrombosis (SVT) on the hemodynamic parameters of hepatic portal system. Based on the CT images of a patient with hepatic portal hypertension and commercial software MIMICS, a real model of hepatic portal vein system was reconstructed. The blood flow velocity in the hepatic portal vein system was measured by color Doppler ultrasound as a simulated inlet boundary condition. Computational fluid dynamics (CFD) method was used to simulate the changes of hemodynamic parameters in the hepatic portal system and to analyze the effects on the physiological process. The results showed that the weight SVT had a serious effect on the hemodynamic parameters of the hepatic portal vein system. When blood flow through SVT, the blood pressure decreases, the flow velocity and wall shear force increase, the resistance of blood flow increases, the velocity of blood flow in the main portal vein slows down, and the pressure gradient decreases. A more uniform distribution of wall shear forces. SVT may lead to a decrease in the ability to supply blood to the liver and increase the likelihood of new thrombosis around the thrombus and in the main portal vein.
【作者单位】：重庆大学动力工程学院;
【分类号】：R575.21

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