新诊断2型糖尿病合并非酒精性脂肪性肝病患者血浆白细胞衍生趋化因子2水平变化及意义

发布时间：2018-03-07 20:46

本文选题：型糖尿病　切入点：非酒精性脂肪性肝病　出处：《实用医学杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的:观察新诊断2型糖尿病(T2DM)合并非酒精性脂肪性肝病(NAFLD)患者血浆白细胞衍生趋化因子2(LECT2)水平变化,并探讨其临床意义。方法:选取研究对象137例,其中新诊断T2DM合并NAFLD患者50例、单纯T2DM患者47例及正常对照者40例,采用酶联免疫吸附法(ELISA)检测血浆LECT2水平,同时进行人体测量及测定各项生化指标。结果:T2DM合并NAFLD患者血浆LECT2水平显著高于单纯T2DM组[(32.95±10.11 vs.29.08±7.54)ng/m L,P0.01],且两组均显著高于正常对照组[(22.38±4.40)ng/m L,P0.01]。血浆LECT2水平与体质指数、血糖、胰岛素、C肽、Hb A1c、γ-谷氨酰基转移酶、三酰甘油、HOMA-IR呈正相关,与高密度脂蛋白胆固醇、HOMA-%β呈负相关(均P0.01)。体质指数、空腹血糖及高密度脂蛋白胆固醇是影响血浆LECT2水平的重要因素。结论:T2DM合并NAFLD患者血浆LECT2水平升高,并与胰岛素抵抗、糖脂代谢紊乱密切相关,提示LECT2可能参与胰岛素抵抗及T2DM的发生发展。
[Abstract]:Objective: to observe the changes of plasma leucocyte derived chemokine (LECT2) and its clinical significance in patients with newly diagnosed type 2 diabetes mellitus (T2DM) with nonalcoholic fatty liver disease (NAFLD). Among them, 50 cases of newly diagnosed T2DM with NAFLD, 47 cases of simple T2DM and 40 cases of normal control were used to detect the plasma LECT2 level by enzyme-linked immunosorbent assay (Elisa). Results the plasma LECT2 level in T2DM patients with NAFLD was significantly higher than that in T2DM patients [32.95 卤10.11 卤7.54 ng / mL P0.01], and both groups were significantly higher than those in the normal control group [22.38 卤4.40 ng / mL P0.01]. HbA1c, 纬 -glutamyl transferase, triacylglycerol HOMA-IR were positively correlated with HbA1c, HbA1c, 纬 -glutamyl transferase and HOMA-IR, and negatively correlated with HOMA-% 尾 (all P 0.01). Body mass index (BMI). Fasting blood glucose and high density lipoprotein cholesterol are important factors affecting plasma LECT2 level. Conclusion the plasma LECT2 level in patients with NAFLD is increased, which is closely related to insulin resistance and disorder of glucose and lipid metabolism. The results suggest that LECT2 may be involved in the development of insulin resistance and type 2 DM.
【作者单位】：南方医科大学珠江医院内分泌代谢科;
【基金】：国家自然科学基金面上项目(编号:81570716)
【分类号】：R575.5;R587.1

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