乌司他丁联合奥曲肽治疗老年急性重症胰腺炎患者的机制

发布时间：2018-03-08 06:29

本文选题：乌司他丁　切入点：奥曲肽　出处：《中国老年学杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的探究乌司他丁联合奥曲肽治疗老年急性重症胰腺炎患者的机制。方法 180例老年急性重症胰腺炎患者,按随机数字表法分为观察组和对照组各90例,对照组给予常规治疗和乌司他丁治疗,观察组在常规治疗基础上给予乌司他丁和奥曲肽治疗,治疗前和治疗后5 d检测两组免疫细胞、炎症因子和血液流变学变化情况。结果两组治疗前免疫细胞、炎症因子和血液流变学指标比较差异无统计学意义(P0.05);治疗后炎症因子白细胞介素(IL)-6、IL-8、肿瘤坏死因子(TNF)-α、C反应蛋白(CRP),血液流变学指标(高切全血比黏度、血浆比黏度、血小板黏附率、血栓长度)均显著降低,且观察组低于对照组,免疫细胞CD3~+、CD4~+、CD4~+/CD8~+均显著升高,且观察组显著高于对照组,CD8~+均显著降低且观察组低于对照组(均P0.05)。结论乌司他丁联合奥曲肽治疗能够改善老年急性重症胰腺炎免疫细胞、炎症因子和血液流变学水平,为急性重症胰腺炎老年患者的临床治疗提供帮助。
[Abstract]:Objective to explore the mechanism of ulinastatin combined with octreotide in the treatment of elderly patients with severe acute pancreatitis. Methods 180 elderly patients with severe acute pancreatitis were randomly divided into observation group (n = 90) and control group (n = 90). The control group was treated with routine therapy and ulinastatin. The observation group was treated with ulinastatin and octreotide on the basis of routine treatment. The immune cells were detected before and 5 days after treatment. Changes in inflammatory factors and hemorheology. Results before treatment, the immune cells in the two groups, There was no significant difference between inflammatory factors and hemorheological indexes (P 0.05). After treatment, there was no significant difference in inflammatory cytokines interleukin-6 (IL-8), tumor necrosis factor TNF- 伪 -C reactive protein (CRPX), hemorheology (high shear whole blood viscosity, plasma viscosity, platelet adhesion rate). The length of thrombus was significantly decreased, and that of the observation group was lower than that of the control group, and the immunocyte CD3 ~ + CD4 ~ + CD4 ~ / CD8 ~ were significantly increased. The levels of CD8 ~ in the observation group were significantly lower than those in the control group (P 0.05). Conclusion Ulinastatin combined with octreotide can improve the levels of immune cells, inflammatory factors and hemorheology in elderly patients with severe acute pancreatitis. To provide assistance for the clinical treatment of elderly patients with severe acute pancreatitis.
【作者单位】：德阳市人民医院消化内科;遵义医学院附属医院消化内科;德阳市人民医院重症医学科;德阳市人民医院检验科;
【基金】：四川省自然科学基金资助项目(201512099)
【分类号】：R576

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