炎症性肠病患者肠道菌群变化及其与炎性因子的相关性

发布时间：2018-03-08 10:01

本文选题：炎症性肠病　切入点：肠道菌群　出处：《山东医药》2015年10期 　论文类型：期刊论文

【摘要】：目的探讨炎症性肠病(IBD)患者肠道菌群的变化,并分析其与炎性因子的相关性。方法选择IBD患者178例,其中活动期112例(活动组)、缓解期66例(缓解组),另选择82例健康查体者作为对照组。采集各组新鲜粪便,使用梯度稀释法定量培养分析肠道菌群;采集静脉血应用ELISA法检测血清IL-6、IL-17、IL-22、IL-33水平。结果与对照组、缓解组比较,活动组粪便中大肠杆菌、肠球菌数量升高,双歧杆菌、乳酸杆菌数量降低,血清IL-6、IL-17、IL-22和IL-33水平升高(P均0.05)。对照组、缓解组各观察指标比较均无统计学差异。大肠杆菌、肠球菌数量与IL-6、IL-17、IL-22和IL-33水平呈正相关,双歧杆菌、乳酸杆菌数量与IL-6、IL-17、IL-22、IL-33水平均呈负相关(P均0.05)。结论 IBD活动期患者存在肠道菌群失衡,后者与炎症的发生密切相关。
[Abstract]:Objective to investigate the changes of intestinal flora in patients with inflammatory bowel disease (IBD) and to analyze its correlation with inflammatory factors. Methods 178 patients with IBD were selected. There were 112 active cases (active group), 66 cases (remission group) (remission group) and 82 healthy examiners as control group. Fresh feces were collected from each group, and the intestinal flora was quantitatively analyzed by gradient dilution method. Results compared with control group and remission group, the number of Escherichia coli, Enterococcus, Bifidobacterium and Lactobacillus in active group were increased, and the number of Bifidobacterium and Lactobacillus were decreased. The levels of IL-17, IL-22 and IL-33 in serum were increased (P < 0.05). There was no significant difference between the observed indexes in control group and remission group. There was a positive correlation between the levels of IL-17 IL-22 and IL-33 in Escherichia coli, Enterococcus, and the levels of IL-17, IL-22 and IL-33, bifidobacterium, Bifidobacterium. There was a negative correlation between the number of lactobacillus and the level of IL-17, IL-22 and IL-33 in patients with IBD. Conclusion there is an imbalance of intestinal flora in patients with active IBD, and the latter is closely related to the occurrence of inflammation.
【作者单位】：山东省交通医院;山东大学齐鲁医院;
【分类号】：R574

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