正常血清尿酸与非酒精性脂肪性肝病的相关性研究

发布时间：2018-03-09 12:30

  本文选题：尿酸　切入点：非酒精性脂肪性肝病　出处：《中国糖尿病杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的研究普通人群中正常SUA与非酒精性脂肪性肝病(NAFLD)的关系。方法收集22209例正常SUA体检者的临床和生化资料并通过腹部B超诊断NAFLD。按照是否存在NAFLD分为非NAFLD(Non-NAFLD)组和NAFLD组,按照性别特异的SUA四分位数分为4组(Q1~Q4)。结果本研究人群中NAFLD的患病率为20.9%。随着SUA水平升高,各组年龄、BMI、SBP、DBP、TG、TC、LDL-C、Scr、谷丙转氨酶(ALT)和谷草转氨酶(AST)均升高,而HDL-C降低(P0.001);Q1组至Q4组,NAFLD患病率逐渐升高(分别为12.3%、16.0%、23.0%和32.6%,P0.001);校正性别、年龄、BMI、血压、血脂后,多元Logistic回归分析显示,Q2~Q4组NAFLD患病风险较Q1组分别增加24%、43%和94%(P0.001)。结论普通人群正常范围内SUA的升高与NAFLD密切相关,可能是其发生的独立危险因素。
[Abstract]:Objective to study the relationship between normal SUA and nonalcoholic fatty liver disease (NAF LDD) in the general population. Methods the clinical and biochemical data of 22209 normal SUA patients were collected and diagnosed by abdominal B-ultrasound. According to the existence of NAFLD, they were divided into non-NAFLDD group and NAFLD group. Results the prevalence rate of NAFLD was 20.9 in this study group. With the increase of SUA level, the levels of NAFLD in all groups were increased, and the levels of NAFLD, alanine aminotransferase (alt) and aspartate aminotransferase (AST) were increased in all groups. However, the prevalence rate of NAFLD in P0.001 / Q1 group and Q4 group increased gradually (12.3%, 16.0% and 32.6% P0.001 respectively), sex, age, blood pressure and blood lipid were adjusted, and the prevalence of NAFLD was increased gradually (P < 0.05), respectively, after adjusting for sex, age, blood pressure and blood lipid, the incidence of NAFLD was significantly higher than that in control group. Multiple Logistic regression analysis showed that the risk of NAFLD in Q2Q4 group was 24% higher than that in Q1 group. Conclusion the increase of SUA in normal population is closely related to NAFLD and may be an independent risk factor.
【作者单位】： 上海交通大学附属第一人民医院内分泌代谢病科;上海交通大学附属第一人民医院松江分院内分泌科;
【基金】：国家自然科学基金青年项目(81400785)
【分类号】：R575.5
，

本文编号：1588559