血清铁蛋白与2型糖尿病合并非酒精性脂肪肝的相关性

发布时间：2018-03-09 14:07

本文选题：型糖尿病　切入点：非酒精性脂肪肝　出处：《山东医药》2017年41期 　论文类型：期刊论文

【摘要】：目的探讨血清铁蛋白(SF)与2型糖尿病(T2DM)合并非酒精性脂肪肝(NAFLD)的相关性。方法收集T2DM患者536例,根据肝胆B超结果分为T2DM+NAFLD组288例,T2DM组248例。收集两组患者的一般临床资料,抽空腹血测定血清铁蛋白(SF)、空腹血糖(FPG)、空腹胰岛素(FINS)、糖化血清蛋白(GSP)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(Apo A1)、载脂蛋白E(Apo E)、转铁蛋白(TRF)等,再根据身高、体质量计算体质量指数(BMI),根据FPG、FINS计算胰岛素抵抗指数(HOMA-IR)。进行相关性分析。结果 T2DM+NAFLD组患者血清SF水平高于T2DM组(P0.05),且WC、BMI、FPG、FINS、HOMA-IR、TG、TRF、Apo E均高于T2DM组(P均0.05),年龄、GSP、Apo A1、HDL-C低于T2DM组(P均0.01)。相关性分析结果显示,T2DM+NAFLD组血清SF水平与男性、FPG、GSP、TG、Apo E呈正相关(r分别为0.364、0.195、0.217、0.209、0.151,P均0.05),与年龄、HDL-C、TRF、Apo A1呈负相关(r分别为-0.178、-0.230、-0.192、-0.172,P均0.01),而偏相关分析结果显示,SF与男性、GSP呈正相关(r分别为0.289、0.145,P均0.05),与年龄、TRF呈负相关(r分别为-0.191、-0.197,P均0.01)。二分类Logistic回归分析结果显示,年龄、性别、SF、BMI、TC、TG、LDL-C、TRF是T2DM合并NAFLD的危险因素(P均0.05)。结论血清SF是T2DM合并NAFLD的危险因素,SF水平升高可增加T2DM合并NAFLD的患病风险。
[Abstract]:Objective to investigate the relationship between serum ferritin ferritin (SF) and type 2 diabetes mellitus (T2DM) combined with NAFLD. Methods 536 patients with T2DM were divided into T2DM NAFLD group (n = 288) and T2DM group (n = 248) according to the results of hepatobiliary B-ultrasound. The general clinical data of the two groups were collected. Determination of serum ferritin (SF), fasting plasma glucose (FPG), fasting insulin (FINSN), glycosylated serum protein (GSPN), total cholesterol TCU, triglyceride (TGN), high density lipoprotein cholesterol (HDL-CU), low density lipoprotein cholesterol (LDL-CU), apolipoprotein A1Apo A1C, apolipoprotein A1apo A1C. Eapo, TRFs, TRFs, etc. And according to height, Body mass index (BMI) was calculated and insulin resistance index (HOMA-IRN) was calculated according to FPGG fins. Results Serum SF level of patients with T2DM NAFLD was higher than that of T2DM patients (P 0.05), and the serum SF level of patients with T2DM NAFLD was higher than that of T2DM patients (P < 0.05), and the serum SF level of patients with T2DM NAFLD was lower than that of T2DM patients (P < 0.05), and the level of serum SF of patients with T2DM was lower than that of T2DM patients (P < 0.01), and the level of serum SF of patients with T2DM was lower than that of T2DM group (P < 0.05). The results of correlation analysis showed that the level of serum SF in T2DM NAFLD group was positively correlated with that of male patients with NAFLD, and the positive correlation r was 0.3640.1950.2170.2170.2090.151 (P < 0.05), and negatively correlated with HDL-CT-RFApo A1 (r = -0.178- 0.230- 0.192ng-0.172P), respectively. The partial correlation analysis showed that SF was positively correlated with male GSP. The results of partial correlation analysis showed that SF was positively correlated with male GSP (P < 0.01), and had a negative correlation with age (P < 0.01), and had a negative correlation with TRFApo A1 (r = -0.178U -0.230U -0.192U -0.172P, P < 0.01). R = 0.289 ~ 0.145 (P = 0.05), and negatively correlated with age, r = -0.191 ~ (-1) -0.197 ~ (-1) P, respectively. The results of two-classification Logistic regression analysis showed that. Age, sex, TGG-LDL-CRF were all risk factors of T2DM with NAFLD. Conclusion Serum SF is a risk factor of T2DM with NAFLD. Elevated SF level may increase the risk of T2DM with NAFLD.
【作者单位】：南京中医药大学大学第一临床医学院;
【基金】：国家自然科学基金资助项目(81503312)
【分类号】：R575.5;R587.1

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