胃苏颗粒联合西药治疗老年GERD的疗效分析

发布时间：2018-03-12 18:34

本文选题：中西医结合　切入点：胃食管反流　出处：《中药材》2017年06期 　论文类型：期刊论文

【摘要】：目的:探讨胃苏颗粒联合西药治疗老年胃食管反流病(GERD)的临床疗效。方法:回顾性分析2015年3月~2016年10月在厦门大学附属第一医院杏林分院接受治疗的GERD老年患者的临床资料。根据其治疗方式分为对照组和观察组,其中对照组给予常规西药治疗,观察组给予胃苏颗粒联合西药治疗。治疗4周后,观察两组患者的治疗效果,比较两组患者治疗前后反流检查计分(RFS)、压痛程度、炎症细胞因子水平、临床症状体征改善情况和不良反应发生率的差异。结果:治疗后观察组总有效率显著高于对照组,RFS、VAS评分及血清IL-18、IL-6、hsCRP水平显著低于对照组,反酸、烧心和腹痛等积分显著低于对照组(P0.05)。两组患者腹泻、肝肾功能受损等不良反应发生率差异无统计学意义。结论:胃苏颗粒联合西药对老年GERD患者有良好的疗效,可缓解症状,降低血清炎症细胞因子水平。
[Abstract]:Objective: To investigate the effects of Weisu Granules Combined with western medicine in the treatment of senile gastroesophageal reflux disease (GERD) patients. Methods: a retrospective analysis of clinical data of March 2015 ~2016 year in October treated in the First Affiliated Hospital of Xiamen University Xinglin branch of GERD in elderly patients. According to the treatment methods are divided into control group and observation group, the control group was given the conventional western medicine treatment, the observation group was given Weisu Granules Combined with western medicine treatment. After 4 weeks of treatment, observe the curative effect of two groups, two groups were compared before and after the treatment of reflux examination score (RFS), tenderness degree, inflammatory cytokines, clinical symptom improvement and adverse reaction rate were compared. Results: treatment after the total efficiency of observation group was significantly higher than the control group, RFS, VAS score and serum IL-18, IL-6, hsCRP were significantly lower than the control group, acid reflux, heartburn and abdominal pain score was significantly lower than the control group (P0.05 ). Two groups of patients with diarrhea, liver and kidney function damage and other adverse reaction rate had no significant difference. Conclusion: Weisu Granules Combined with western medicine has good curative effect on elderly patients with GERD, can alleviate the symptoms, reduce serum levels of inflammatory cytokines.

【作者单位】：厦门大学附属第一医院杏林分院中医科;
【分类号】：R571

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