重症急性胰腺炎患者早期应用微创置管引流的治疗效果评价

发布时间：2018-03-14 22:21

本文选题：胰腺炎　切入点：急性坏死性　出处：《中国全科医学》2017年S1期 　论文类型：期刊论文

【摘要】：目的探讨重症急性胰腺炎患者早期应用微创置管引流的治疗效果。方法选取2012年6月—2015年12月西南医科大学附属医院消化内科收治的90例重症急性胰腺炎患者为研究对象,随机分为研究组和对照组,各45例。对照组进行常规治疗,研究组进行微创置管引流治疗。观察并比较两组患者各炎性因子的变化、全身炎症反应综合征(SIRS)持续时间、肠道功能恢复时间以及多器官功能障碍综合征(MODS)的发生率。结果治疗后3 d、7d两组患者的TNF-α、CPR、IL-6低于治疗前,差异有统计学意义(P0.05);治疗后7 d两组患者的IL-8低于治疗前,差异有统计学意义(P0.05);治疗后3 d、7 d研究组的TNF-α、CPR、IL-6低于对照组,差异有统计学意义(P0.05);治疗后7 d,研究组IL-8低于对照组,差异有统计学意义(P0.05);研究组患者的SIRS持续时间、肠道功能恢复时间均短于对照组,差异有统计学意义(P0.05);研究组患者MODS发生率低于对照组,差异有统计学意义(P0.05)。结论重症急性胰腺炎患者早期应用微创置管引流能够降低炎性因子的水平,缓解炎性症状,并能缩短SIRS持续时间和肠道功能恢复时间,降低MODS发生率,临床疗效优于穿刺置管引流,值得推广应用。
[Abstract]:Objective to investigate the effect of early application of minimally invasive tube drainage in patients with severe acute pancreatitis. Methods from June 2012 to December 2015 90 patients with severe acute pancreatitis admitted in the Department of Digestive Medicine affiliated Hospital of Southwest Medical University were selected as study objects. Two groups were randomly divided into two groups: the control group (n = 45) and the control group (n = 45). The patients in the control group were treated with routine therapy and the patients in the study group were treated with minimally invasive tube drainage. The changes of inflammatory factors and the duration of systemic inflammatory response syndrome (SIRS) were observed and compared between the two groups. Results the levels of TNF- 伪 CPR- 6 in the two groups were significantly lower than those before treatment at 3 days and 7 days after treatment, and the IL-8 of the two groups was lower than that of before treatment on the 7th day after treatment (P < 0.05), but at the 7th day after treatment, the IL-8 of the two groups was lower than that of the patients before and after treatment, and there was a significant difference in the recovery time of intestinal function and the incidence of multiple organ dysfunction syndrome. The difference was statistically significant (P 0.05), the level of TNF- 伪 IL-8 6 in the study group was lower than that in the control group 3 days after treatment, the difference was statistically significant (P 0.05), the IL-8 in the study group was lower than that in the control group at 7 d after treatment, and the difference was statistically significant (P 0.05). The duration of SIRS in the study group was significantly lower than that in the control group. The recovery time of intestinal function was shorter than that of control group (P 0.05), the incidence of MODS in study group was lower than that in control group. Conclusion early application of minimally invasive catheter drainage in patients with severe acute pancreatitis can reduce the level of inflammatory factors, alleviate inflammatory symptoms, shorten the duration of SIRS and the recovery time of intestinal function, and reduce the incidence of MODS. The clinical effect is better than that of puncture and drainage, so it is worth popularizing and applying.
【作者单位】：西南医科大学附属医院消化内科;
【分类号】：R576

【相似文献】