决明降脂片与多烯磷脂酰胆碱胶囊治疗非酒精性脂肪肝的临床研究

发布时间：2018-03-14 22:35

  本文选题：多烯磷脂酰胆碱胶囊　切入点：决明降脂片　出处：《中国临床药理学杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的观察多烯磷脂酰胆碱胶囊联合决明降脂片治疗非酒精性脂肪肝临床疗效及安全性。方法 62例非酒精性脂肪肝患者随机分为对照组31例与试验组31例。对照组给予多烯磷脂酰胆碱胶囊456 mg,每日3次,口服;试验组在对照组的基础上给予决明降脂片2.7 g,每日3次,口服。2组患者均治疗2个月。比较2组患者的临床疗效、瘦素、肝功能水平及药物不良反应发生情况。结果治疗后,试验组总有效率为87.10%(27/31例),对照组为64.52%(20/31例,P0.05)。治疗后,对照组和试验组血清瘦素分别为(1.08±0.17),(0.76±0.89)μg·L~(-1),谷丙转氨酶分别为(50.82±5.59),(34.97±4.03)U·L~(-1),谷草转氨酶分别为(54.92±6.02),(40.25±4.53)U·L~(-1),总胆红素分别为(30.11±3.35),(27.89±3.09)μmol·L~(-1),直接胆红素分别为(18.02±2.01),(13.60±1.67)μmol·L~(-1),白蛋白分别为(35.92±4.45),(42.03±4.70)g·L~(-1),差异均有统计学意义(P0.05)。试验组出现的药物不良反应有轻微胃肠道紊乱、眩晕头痛、皮疹,药物不良反应发生率为9.68%(3/31例);对照组出现的药物不良反应有眩晕头痛、眩晕头痛、皮疹、肝硬化,药物不良反应发生率为22.58%(7/31例),2组药物不良反应率差异无统计学意义(P0.05)。结论多烯磷脂酰胆碱胶囊联合决明降脂片治疗非酒精性脂肪肝的临床疗效较高,安全性高。
[Abstract]:Objective To observe the combined Polyene Phosphatidylcholine Capsules Jueming Jiangzhi tablets in the treatment of clinical efficacy and safety of nonalcoholic fatty liver disease. Methods 62 cases of nonalcoholic fatty liver patients were randomly divided into control group of 31 cases and 31 cases in the experiment group. The control group was given the Polyene Phosphatidylcholine Capsules 456 mg, 3 times daily oral; in the experimental group, the control group based on the given tree Jiangzhi tablets 2.7 g, 3 times a day, oral.2 patients were treated for 2 months. The clinical curative effect of leptin, compared 2 groups of patients, the incidence of the adverse reactions of liver function and drugs. Results after treatment, the test group total effective rate was 87.10% (27/31 cases), the control group was 64.52% (20/31 cases, P0.05). After treatment, the serum leptin control group and test group respectively (1.08 + 0.17), (0.76 + 0.89) g - L~ (-1), alanine aminotransferase were (50.82 + 5.59), (34.97 + 4.03) U - L~ (-1), aspartate aminotransferase (54.92 + 6.02 respectively.), (40.25 + 4.53) U L~ (-1), total bilirubin were (30.11 + 3.35), (27.89 + 3.09) mol - L~ (-1), direct bilirubin were (18.02 + 2.01), (13.60 + 1.67) mol - L~ (-1), albumin were (35.92 + 4.45), (42.03. 4.70) g - L~ (-1), the difference was statistically significant (P0.05). The drug adverse reaction in the experimental group appeared to have mild gastrointestinal disorders, vertigo, headache, rash, the incidence of adverse reaction was 9.68% (3/31 cases); the control group appeared adverse drug reactions were dizziness headache, dizziness, headache, rash, liver cirrhosis, the incidence of adverse reaction was 22.58% (7/31 cases), 2 groups of adverse drug reaction rate had no significant difference (P0.05). Conclusion high clinical efficacy Polyene Phosphatidylcholine Capsules Jueming Jiangzhi pill in the treatment of nonalcoholic fatty liver, high safety.

【作者单位】： 杭州师范大学附属医院药学部;杭州师范大学附属医院肝科外科;
【基金】：浙江省自然科学基金资助项目(LQ16H290003)
【分类号】：R575.5

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