HLA-DQA1基因拷贝数变异与乙型肝炎病毒感染后不同转归的易感性

发布时间：2018-03-15 08:25

本文选题：乙型肝炎病毒　切入点：人类白细胞相关抗原DQA　出处：《安徽医科大学学报》2017年07期 　论文类型：期刊论文

【摘要】：目的探讨人类白细胞抗原(HLA)DQAl基因拷贝数变异(CNV)与中国汉族人群乙型肝炎病毒(HBV)感染后不同转归和疾病进展的关系。方法采用AccuC opy CNV检测技术检测825例慢性HBV感染患者和287例急性自限性HBV感染者的HLA-DQAl基因CNV,采用χ2检验等分析HLA-DQA1 CNV与HBV感染后慢性化和疾病进展的发病风险。结果在HBV感染后急慢性转归方面,急性自限性HBV感染组HLA-DQA1拷贝数2的比例显著高于慢性HBV感染组(15.3%vs 6.9%,χ2=25.22,P0.001)。在慢性HBV感染后疾病进展方面,随疾病进展,HLA-DQAl基因拷贝数2的比例在慢性乙型肝炎(CHB)组、肝硬化(LC)组和肝癌(HCC)组3组间逐渐增加,分别为10.1%,15.3%和27.9%,差异有统计学意义(χ2=25.66,P0.001)。根据E抗原分组分析显示,E抗原阳性患者组和E抗原阴性患者组HLA-DQA1 CNV的比例无显著性差异。结论 HLA-DQA1基因CNV是HBV感染慢性化的遗传易感因素,HLA-DQA1基因拷贝数减少可能是HBV感染慢性化和疾病进展的危险因素。
[Abstract]:Objective to investigate the relationship between the variation of HLA-DQAl gene copy number of human leukocyte antigen (HLA-DQAl) and the outcome and progression of hepatitis B virus (HBV) infection in Chinese Han population. Methods the AccuC opy CNV technique was used to detect 825 cases of chronic HBV infection. The HLA-DQAl gene of patients and 287 patients with acute self-limited HBV infection were analyzed by 蠂 2 test. The risk of chronic HLA-DQA1 CNV and HBV infection and disease progression were analyzed by 蠂 2 test. The ratio of HLA-DQA1 copy number 2 in acute self-limited HBV infection group was significantly higher than that in chronic HBV infection group (15.3 vs 6.9). There was a gradual increase in the number of patients with liver cirrhosis in LC group and HCCgroup in liver cancer group. There was no significant difference in the proportion of HLA-DQA1 CNV between E antigen positive patients and E antigen negative patients according to E antigen grouping analysis. Conclusion HLA-DQA1 gene CNV is chronic in HBV infection. The decrease of HLA-DQA1 copy number may be the risk factor of chronic infection and disease progression of HBV.
【作者单位】：安徽医科大学阜阳传染病临床学院(阜阳市第二人民医院)肝病科;安徽医科大学第二附属医院肝病科;六安市人民医院感染病科;
【基金】：国家自然科学基金(编号:81273142)
【分类号】：R512.62

【相似文献】