抗GP210抗体和抗SP100抗体对原发性胆汁性肝硬化诊断价值的meta分析

发布时间：2018-03-16 02:30

本文选题：抗GP210抗体　切入点：抗SP100抗体　出处：《重庆医科大学》2016年硕士论文　论文类型：学位论文

【摘要】：背景与目的:原发性胆汁性肝硬化(primary biliary cirrhosis,PBC)是一种慢性肝内胆汁淤积性疾病,最终可发展为肝硬化和肝衰竭,病因尚不清楚,发病率逐年上升。PBC患者的诊断对其预后至关重要。系统评价抗GP210抗体和抗SP100抗体对PBC的诊断价值。方法:计算机检索Cochrane图书馆、MEDLINE、维普中文科技期刊数据库(VIP)、中文科技期刊全文数据库(CNKI)、中国学位论文全文数据库(万方)。按文内所述纳入标准收集抗GP210抗体和抗SP100抗体诊断PBC的研究,采用QUADAS量表进行质量评价,利用Meta-disc1.4及Rev Man5.2软件进行数据分析,绘制SROC曲线。结果:检索后共纳入25项抗GP210抗体和21项抗SP100抗体的研究。抗GP210抗体对原发性胆汁性肝硬化的诊断优势比(DOR)、汇总灵敏度和汇总特异度分别是24.854(95%CI,11.957 51.660)、0.272(95%CI,0.257 0.288)和0.985(95%CI,0.982 0.988),抗SP100抗体DOR、汇总灵敏度和汇总特异度分别是9.133(95%CI,4.739 17.600)、0.231(95%CI,0.213 0.249)和0.977(95%CI,0.973 0.981)。结论:抗GP210抗体和抗SP100抗体对于原发性胆汁性肝硬化诊断特异度高,但灵敏度较低。
[Abstract]:Background & AIM: primary biliary cirrhosis of primary biliary cirrhosis is a chronic intrahepatic cholestasis disease, which can eventually develop into cirrhosis and liver failure. The diagnostic value of anti GP210 antibody and anti SP100 antibody in the diagnosis of PBC was evaluated systematically. Methods: to search Cochrane library for MEDLINE, Weipu Chinese science and technology journal database, Chinese, Chinese, etc. The full text Database of Sci-tech Journals (CNKI), the full text Database of Chinese academic dissertations (Wan Fang). The research on the diagnosis of PBC by anti GP210 antibody and anti SP100 antibody according to the inclusion standard mentioned in the paper, QUADAS scale was used for quality evaluation, and Meta-disc1.4 and Rev Man5.2 software were used for data analysis. SROC curves were drawn. Results: after retrieval, 25 anti GP210 antibodies and 21 anti SP100 antibodies were included. The diagnostic advantage of anti GP210 antibody in primary biliary cirrhosis was higher than that of GP210 antibody. The sum sensitivity and aggregation specificity of anti GP210 antibody were 24.854 5 95 CI 11.957 0. 27295 CI 0.257 0.288 respectively. The sum sensitivity and specificity of anti SP100 antibody were 9.133C95CIQ 4.739 and 17.600,0.231CI0.213 0.249and 0.97795CII 0.973 0.981.Conclusion: the specificity of anti GP210 antibody and anti SP100 antibody in the diagnosis of primary biliary cirrhosis is high, and the specificity of anti GP210 antibody and anti SP100 antibody is higher than that of anti SP100 antibody in the diagnosis of primary biliary cirrhosis, and the total sensitivity and specificity of anti SP100 antibody are 9. 133% and 0. 231 卤0. 249, respectively. Conclusion: anti GP210 antibody and anti SP100 antibody are of high specificity in the diagnosis of primary biliary cirrhosis. But the sensitivity is low.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R575.22

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