自发性细菌性腹膜炎患者可溶性髓样细胞触发受体1表达研究

发布时间：2018-03-17 01:41

本文选题：腹膜炎　切入点：腹腔积液　出处：《中国全科医学》2017年14期 　论文类型：期刊论文

【摘要】：目的探讨可溶性髓样细胞触发受体1(sTREM-1)在自发性细菌性腹膜炎(SBP)患者中的表达情况。方法选取2013年6月—2014年12月绍兴市人民医院消化内科收治的肝硬化腹腔积液患者,23例并发SBP的患者为SBP组,66例未并发SBP的患者为非SBP组,SBP组患者根据病情分为轻症SBP(14例)和重症SBP(9例)。检测其血清白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)、sTREM-1水平及腹腔积液细胞、多形核白细胞计数(PMN)、乳酸脱氢酶(LDH)、sTREM-1水平。结果 SBP组血清WBC、CRP、PCT、sTREM-1及腹腔积液细胞、PMN、LDH、sTREM-1水平均较非SBP组升高(P0.05)。非SBP组腹腔积液培养均为阴性,SBP组细菌培养13例(56.5%)患者阳性。轻症及重症SBP患者血清WBC、CRP、PCT、sTREM-1及腹腔积液细胞、PMN、LDH、sTREM-1水平比较,差异均无统计学意义(P0.05)。Pearson相关性分析显示,SBP组和非SBP组患者血清sTREM-1水平与腹腔积液sTREM-1水平呈正相关(r=0.737,P0.001;r=0.275,P=0.025)。结论肝硬化腹腔积液并发SBP患者血清和腹腔积液sTREM-1水平升高,但是不同病情程度患者无差异,sTREM-1有可能作为诊断SBP的参考指标。
[Abstract]:Objective to investigate the expression of soluble myeloid cell trigger receptor (sTREM-1) in patients with spontaneous bacterial peritonitis (SBP). Among the 23 patients complicated with SBP, 66 patients without SBP in SBP group were divided into mild SBP(14 group and severe SBP(9 group according to their condition. The serum leukocyte count and the levels of serum WBC C reactive protein, procalcitonin TREM-1 and peritoneal effusion cells were measured. Results in SBP group, the levels of serum WBCG-CRP- PCTnm-1 and peritoneal effusion cells were significantly higher than those of non-#en1# group. The positive rate of bacterial culture in non-SBP group was 13 cases (56.5%), while that in non-#en2# group was negative (13 cases, 56.5%), compared with that in non-#en1# group (P < 0.05), and the level of TREM-1 was significantly higher than that in control group (P < 0.05), and the level of TREM-1 was significantly higher than that in control group (P < 0.01). The positive levels of TREM-1 in SBP group were significantly higher than those in control group (P < 0.05). Serum levels of TREM-1 in patients with mild or severe SBP were compared with those in peritoneal effusion cells. There was no significant difference between serum sTREM-1 level and sTREM-1 level in peritoneal effusion of patients with SBP. Conclusion the levels of sTREM-1 in serum and peritoneal effusion in patients with cirrhosis and peritoneal effusion complicated with SBP were significantly higher than those in control group and non-SBP group, and there was a positive correlation between the serum sTREM-1 level and the sTREM-1 level in peritoneal effusion. Conclusion there is a positive correlation between the level of serum sTREM-1 and the level of sTREM-1 in peritoneal effusion. Conclusion the level of sTREM-1 in serum and peritoneal effusion is increased in patients with cirrhosis and peritoneal effusion. However, there was no difference between patients with different severity of disease and serum TREM-1 might be used as a reference index for the diagnosis of SBP.
【作者单位】：浙江省绍兴市人民医院消化内科;浙江省绍兴市人民医院神经内科;浙江省绍兴市人民医院中心实验室;
【基金】：绍兴市科技局资助项目(2013B70078)
【分类号】：R572.2

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