血浆置换联合胰岛素强化降糖对高脂血症性胰腺炎患者相关指标的影响

发布时间：2018-03-21 06:01

  本文选题：高脂血症性胰腺炎　切入点：血浆置换　出处：《中国药房》2017年30期 　论文类型：期刊论文

【摘要】：目的:探讨血浆置换联合胰岛素强化降糖对高脂血症性胰腺炎患者相关指标的影响。方法:120例高脂血症性胰腺炎患者随机分为对照组(60例)和观察组(60例)。两组患者在常规治疗的基础上,于入住重症监护病房(ICU)72 h内连续进行3次血浆置换+皮下注射注射用低分子肝素钙5 000单位+静脉推注注射用甲泼尼龙琥珀酸钠40 mg和葡萄糖酸钙注射液2 g。在此基础上,对照组患者随机血糖浓度≥12 mmol/L时,给予胰岛素注射液,微量泵泵入至随机血糖12 mmol/L;观察组患者随机血糖浓度8.3 mmol/L时,给予胰岛素注射液,微量泵持续静脉输注1周,维持随机血糖浓度在6.1~8.3 mmol/L。观察两组患者治疗前后血浆三酰甘油、淀粉酶、降钙素原水平和白细胞计数、全身评分系统研究评分(APACHEⅡ)、局部评分系统研究(Balthazar CT)评分、ICU住院时间及不良反应发生情况。结果:治疗后,两组患者血浆三酰甘油、淀粉酶、降钙素原水平和白细胞计数、APACHEⅡ评分、Balthazar CT评分均显著低于同组治疗前,且观察组显著低于对照组,差异均有统计学意义(P0.05)。观察组患者ICU住院时间显著短于对照组,差异有统计学意义(P0.05)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:血浆置换联合胰岛素强化降糖能有效降低高脂血症性胰腺炎患者血浆三酰甘油水平,缓解炎症反应,改善预后,且未增加不良反应的发生。
[Abstract]:Objective: to investigate the effect of plasma exchange combined with insulin intensive hypoglycemia on the related indexes of hyperlipidemic pancreatitis. Methods: 120 cases of hyperlipidemic pancreatitis were randomly divided into two groups: control group (n = 60) and observation group (n = 60). On the basis of routine treatment, Within 72 hours after admission to intensive care unit (ICU), three consecutive plasma exchange subcutaneous injection of low molecular weight heparin calcium 5 000 units of sodium methylprednisolone succinate 40 mg and calcium gluconate injection 2 g were performed. The patients in the control group were given insulin injection at random blood glucose concentration 鈮，

本文编号：1642567