磁共振DWI对慢性乙型肝炎肝纤维化程度和活动度的评价

发布时间：2018-03-22 01:33

本文选题：磁共振弥散加权成像　切入点：乙型肝炎　出处：《重庆医学》2015年14期 　论文类型：期刊论文

【摘要】：目的探讨磁共振弥散加权成像(DWI)评价慢性乙型肝炎肝纤维化程度和肝炎活动度的价值。方法设置不同的弥散敏感系数b值对102例慢性乙型肝炎患者(肝炎组)和26例健康志愿者(对照组)进行磁共振DWI检查,测定并比较两组肝脏感兴趣区的表观弥散系数(ADC)值。肝炎组进一步分为纤维化组(n=74)和无纤维化组(n=28)。结果设置b值为100和200s/mm2时,两组ADC值比较差异无统计学意义(P0.05);b值为400、600和800s/mm2时,肝炎组ADC值低于对照组,肝纤维化组ADC值低于无纤维化组,差异有统计学意义(P0.05);b值为600及800s/mm2时,肝纤维化组S3及S4期ADC值低于S0及S1期,差异有统计学意义(P0.05);b值为100、200和400s/mm2时,不同肝纤维化程度分期ADC值间的差异无统计学意义(P0.05);b值为800s/mm2时,不同炎症活动度组G1与G4级的ADC值的差异有统计学意义(P0.01),其余组间差异无统计学意义(P0.05)。结论磁共振DWI技术在评价不同分期慢性乙型肝炎肝纤维化程度和活动度方面具有较好的应用价值,设置b值为800s/mm2时,效果最佳。
[Abstract]:Objective to investigate the value of diffusion-weighted Mr imaging (DWI) in evaluating the degree of hepatic fibrosis and hepatitis activity in patients with chronic hepatitis B. methods different values of diffusion-sensitive coefficient b were used in 102 patients with chronic hepatitis B (hepatitis group) and in patients with chronic hepatitis B (hepatitis group). 26 healthy volunteers (control group) underwent MRI DWI examination. The apparent diffusion coefficient (ADC) of the two groups was measured and compared. The hepatitis group was further divided into two groups: the fibrosis group (n = 74) and the group without fibrosis (n = 28). Results when the b value was set to 100 and 200s/mm2, there was no significant difference between the two groups when the ADC value of the two groups was 400600 and 800s/mm2. The ADC value of hepatitis group was lower than that of control group, and the ADC value of hepatic fibrosis group was lower than that of non-fibrosis group. The difference was statistically significant when the value of P0.05nb was 600 and 800s/mm2, and the ADC values of S3 and S4 phases in hepatic fibrosis group were lower than those in S0 and S1 phases, and the difference was statistically significant when P0.05nb value was 100200 and 400s/mm2. There was no significant difference in ADC value between different stages of hepatic fibrosis. When the value of P0.05B was 800s/mm2, there was no significant difference between the ADC values of different stages of hepatic fibrosis. There was significant difference in ADC between G1 and G4 grade in different inflammatory activity groups, but there was no significant difference in other groups. Conclusion MRI DWI technique can be used to evaluate the liver fibrosis degree and activity of chronic hepatitis B patients with different stages. The mask has good application value, When the b value is set to 800s / mm2, the best effect is obtained.
【作者单位】：浙江省长兴县中医院放射科;复旦大学附属华山医院感染科;
【基金】：国家自然科学基金资助项目(81071354)
【分类号】：R512.62;R575;R445.2

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