MR灌注加权成像评价兔肝纤维化分期的实验研究

发布时间：2018-03-23 08:24

  本文选题：肝硬化　切入点：动物　出处：《中国临床医学影像杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的 :应用MR灌注成像(PWI)评价兔肝纤维化分期的诊断价值。方法 :在造模12周后对实验组(n=40)、对照组(n=10)分别进行MR灌注扫描,并对所得到峰值时间(TP),信号上升最大斜率、信号下降最大斜率与病理分期做对照,采用单因素方差分析(One-Way Anova),组间两两比较采用最小显著差法(LSD)。对不同时期的肝纤维化分期的诊断效能进行ROC曲线分析。结果:肝实质峰值时间随着肝纤维化程度的增加逐渐上升,而随着肝纤维化程度的增加信号上升最大斜率和信号下降最大斜率呈下降趋势,对于峰值时间,S0、S1、S2期与S3、S4期有统计学意义(P0.05),最大上升斜率两两比较后发现,S0、S2期与S3、S4期差异有统计学意义(P0.05)。最大下降斜率两两比较后显示,S0、S1、S2期与S3、S4期差异有统计学意义(P0.05)。合并纤维化分期进行比较(S0与≥S1,≤S1与≥S2,≤S2与≥S3,≤S3与S4)差异有统计学意义(P0.05)。结论 :结合峰值时间和信号上升最大斜率能够反映肝纤维化各期灌注变化,对S2期以上的肝纤维化的诊断效能最佳。
[Abstract]:Objective: to evaluate the diagnostic value of Mr perfusion imaging (PWI) in the staging of hepatic fibrosis in rabbits. Methods: Mr perfusion scanning was performed in the experimental group and control group after 12 weeks. The maximum slope of signal descent was compared with pathological stage. One-Way AnovaA was used in univariate ANOVA. The ROC curve was used to analyze the diagnostic efficacy of hepatic fibrosis stages in different stages. Results: the peak time of hepatic parenchyma increased with the increase of hepatic fibrosis degree. However, with the increase of the degree of hepatic fibrosis, the maximum slope of signal rising and the maximum slope of signal decreasing showed a downward trend. For the peak time of S0, S1, S1, S2, and S3, S4, there was a significant difference between S0, S0, S1, S2, S0, S1, S4, S0, S1, S4, and S0, S1, S2, S3, S4, and S0, S1, S2, S3, S4, and S0, S1, S2, S0, S1, S4, S0, S1, S4, S0, S1, S4, and S0, S1, S2, S3, S4. There were significant differences between S0 and 鈮，

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