磁共振体素内不相干运动成像诊断肝纤维化的初步研究

发布时间：2018-03-26 05:26

本文选题：肝纤维化　切入点：扩散加权成像　出处：《放射学实践》2015年07期

【摘要】：目的:采用磁共振体素内不相干运动(IVIM)扩散成像,获得正常志愿者和不同病理分期肝纤维化患者肝脏的磁共振IVIM扩散成像相关信号值(D、f、D*),为临床评估肝纤维化提供一种无创、安全和简便的检测方法。方法:对39例不同病理分期的肝纤维化患者(S1期15例,S2期10例,S3及S4期14例)及19例健康志愿者进行肝脏磁共振IVIM扩散成像。取多b值(10,20,40,60,80,100,150,200,400,800s/mm2),经过分析和公式SI(b)=SI0[(1-f)·exp(-b·D)+f·exp(-b·D*)]非线性回归计算获得D、f、D*值,采用统计学分析正常肝脏和纤维化肝脏之间、肝纤维化不同病理分期之间肝脏的D、f、D*值差异。结果:肝纤维化组和健康组的肝脏磁共振体素内不连贯运动成像扫描参数D、f、D*值分别是0.940±0.129和1.089±0.127(10-3 mm2/s,P0.001),0.126±0.026和0.163±0.018(P0.001),9.616±1.747和12.715±2.335(10-3 mm2/s,P0.001)。结果显示肝纤维化患者的D、f、D*值均显著减低。随着肝纤维化程度的进展,f、D*值持续下降,差异具有统意义(P≤0.001)。结论:磁共振IVIM扩散成像研究发现纤维化肝脏D、f、D*值降低,f值与D*值的降低与肝纤维化程度相关,为评价肝纤维化的严重程度提供了依据。
[Abstract]:Objective: to obtain the IVIM diffusion signal values of liver in normal volunteers and patients with hepatic fibrosis in different pathological stages by using VMI diffusion imaging, so as to provide a noninvasive method for clinical evaluation of hepatic fibrosis. Methods: Mr IVIM diffusion imaging of liver was performed in 39 patients with hepatic fibrosis with different pathological stages, including 15 patients with stage S1 and 14 patients with stage S4) and 19 healthy volunteers. After the analysis and formula SI(b)=SI0 [1-ff exp(-b D] f exp(-b DU], the value of D ~ * is obtained by nonlinear regression calculation. Using statistical analysis between normal liver and fibrosis liver, Results: the DfMr D* values of hepatic MRI in hepatic fibrosis group and healthy group were 0.940 卤0.129 and 1.089 卤0.127 mm ~ (-2) mm ~ (-1) P ~ (0.001) 卤0.026 and 0.163 卤0.018 P ~ (0.001) ~ (-1) ~ (9.616 卤1.747) and 12.715 卤2.335 ~ (-3) mm ~ (-2) mm ~ (-2) P ~ (0.001) respectively. As the degree of hepatic fibrosis progressed, the value of D * decreased significantly in patients with hepatic fibrosis. Conclusion: IVIM diffusion imaging showed that the decrease of D * value of hepatic fibrosis was related to the degree of hepatic fibrosis, which provided a basis for evaluating the severity of hepatic fibrosis.
【作者单位】：深圳市第三人民医院放射科;
【基金】：深圳市知识创新计划重点项目(JCYJ20130401164750006) 深圳市科技计划项目(201302099)
【分类号】：R445.2;R575.2

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