非酒精性脂肪性肝病患者血清PTX3的水平及临床意义

发布时间：2018-03-26 11:58

本文选题：非酒精性脂肪性肝病　切入点：五聚蛋白　出处：《中国老年学杂志》2015年15期

【摘要】：目的探讨非酒精性脂肪肝病患者血清五聚蛋白(PTX)3水平及其临床意义。方法选取2013年2月至2015年2月非酒精性脂肪肝性病患者130例(研究组),根据是否合并肝炎分为肝炎组(n=48例)和非肝炎组(n=82例),另选健康体检者130例(对照组),应用Spearman分析PTX3的参数,应用Logistic回归分析危险因子、ROC对脂肪肝炎的诊断价值。结果研究组血清中PTX3水平显著低于对照组,且肝炎组显著低于非肝炎组(P0.05);Spearman分析显示:胰岛素抵抗指数(HOMA-IR)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、腹腔内脂肪面积(VAT)、腹壁皮下脂肪面积(SAT)以及超敏C反应蛋白(hs-CRP)均为PTX3的相关因素;Logistic回归分析显示:PTX3是非酒精性脂肪肝的保护因素,而HOMA-IR、hs-CRP以及SAT为非酒精性脂肪性肝病的危险因素;血清PTX3诊断非酒精性脂肪性肝病ROC下面积为0.962,鉴别肝炎合并非酒精性脂肪性肝病和单纯性非酒精性脂肪性肝病的最佳截点为1.45 ng/ml。结论血清PTX3为非酒精性脂肪肝病的保护因素,能鉴别非酒精性脂肪性肝病是否合并肝炎。
[Abstract]:Objective to investigate the serum levels of PTX3 in patients with non-alcoholic fatty liver disease and its clinical significance. Methods 130 patients with non-alcoholic fatty liver disease were selected from February 2013 to February 2015. Spearman was used to analyze the parameters of PTX3 in 48 cases of hepatitis group and 82 cases of non-hepatitis group, and 130 cases of healthy persons (control group). Logistic regression analysis was used to analyze the diagnostic value of ROC in fatty hepatitis. Results the serum PTX3 level in the study group was significantly lower than that in the control group. The results of Spearman analysis showed that the insulin resistance index (HOMA-IRN), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), alanine aminotransferase (alt), aspartate aminotransferase (AST), abdominal fat area (VATT), abdominal wall were significantly lower in hepatitis group than those in non-hepatitis group. Both subcutaneous fat area (sat) and hypersensitive C-reactive protein hs-CRP (hs-CRP) were related factors of PTX3. Logistic regression analysis showed that: PTX3 was a protective factor for non-alcoholic fatty liver. HOMA-IRN hs-CRP and SAT were the risk factors of non-alcoholic fatty liver disease. The area under ROC in the diagnosis of non-alcoholic fatty liver disease with serum PTX3 was 0.962.The best cut-off point for differentiating hepatitis with non-alcoholic fatty liver disease and simple non-alcoholic fatty liver disease was 1.45 ng / ml. Conclusion Serum PTX3 is a protective factor for non-alcoholic fatty liver disease. Be able to distinguish non-alcoholic fatty liver disease with hepatitis.
【作者单位】：河北大学附属医院贵宾病房;河北大学医学部;河北大学附属医院消化内科;
【分类号】：R575.5

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