3种用药方案治疗幽门螺杆菌感染活动性慢性胃炎的临床观察

发布时间：2018-03-27 11:42

本文选题：奥美拉唑　切入点：阿莫西林　出处：《中国药房》2016年30期

【摘要】：目的:观察3种用药方案治疗幽门螺杆菌(Hp)感染活动性慢性胃炎的Hp根除情况和安全性。方法:150例Hp感染活动性慢性胃炎患者随机分为A组(50例)、B组(50例)和C组(50例)。A组患者给予奥美拉唑肠溶胶囊20 mg,口服,每日2次+阿莫西林胶囊1.0 g,口服,每日3次+克拉霉素片0.5 g,口服,每日1次。B组患者在A组治疗的基础上给予胶体果胶铋胶囊150 mg,口服,每日3次。C组患者第1~5天给予奥美拉唑肠溶胶囊20 mg,口服,每日2次+阿莫西林胶囊1.0 g,口服,每日3次,第6~10天给予奥美拉唑肠溶胶囊20 mg,口服,每日2次+克拉霉素片0.5 g,口服,每日1次+甲硝唑片0.4 g,每日2次。各组患者疗程均为10 d。观察各组患者疼痛缓解有效率、疼痛缓解时间、消化道症状缓解时间、Hp根除率、随访12个月的复发情况及不良反应发生情况。结果:疼痛缓解有效率、Hp根除率C组B组A组,疼痛缓解时间、消化道症状缓解时间、复发率C组B组A组,差异均有统计学意义(P0.05)。不良反应发生率C组A、B组,差异均有统计学意义(P0.05),但A、B组间比较差异无统计学意义(P0.05)。结论:分阶段服用奥美拉唑联合抗菌药物治疗Hp感染活动性慢性胃炎可有效缓解患者胃部疼痛,缩短病程,提高Hp根除率,降低远期复发率,且安全性较好。
[Abstract]:Objective: to observe the eradication and safety of HP in the treatment of active chronic gastritis with Helicobacter pylori (HP) infection. Methods: 150 patients with active chronic gastritis with HP infection were randomly divided into two groups: group A (n = 50) and group B (n = 50). Group A (n = 50) received omeprazole enteric-coated capsule (20mg) orally. Amoxicillin capsules 1.0 g, oral, clarithromycin tablets 0.5 g, oral, group B once a day, on the basis of treatment in group A, 150 mg colloidal bismuth pectin capsules were given orally. The patients in group C were given omeprazole enteric-coated capsule 20 mg daily, amoxicillin capsule 1.0 g twice daily, three times daily, and omeprazole enteric-coated capsule 20 mg on day 610. Clarithromycin tablets 0.5 g daily, oral, metronidazole tablets 0.4 g once daily, twice daily. The course of treatment was 10 days. The effective rate of pain relief, the time of pain relief, the time of remission of digestive tract symptoms and the eradication rate of HP were observed. Results: the effective rate of pain relief and HP eradication rate group C group B group, pain relief time, digestive tract symptom relief time, recurrence rate C group B group A group. The incidence of adverse reactions in group C was significantly higher than that in group A (P 0.05). The difference was statistically significant (P 0.05), but there was no significant difference between group A and group B (P 0.05). Conclusion: Omeprazole combined with antimicrobial agents in the treatment of active chronic gastritis with HP infection can effectively relieve the pain of stomach and shorten the course of disease in patients with HP infection. It is safe to improve HP eradication rate and reduce long-term recurrence rate.
【作者单位】：武汉市黄陂区人民医院;
【分类号】：R573.3

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