门冬氨酸钾镁与腺苷蛋氨酸对胆汁淤积性病毒性肝炎的临床疗效研究

发布时间：2018-03-28 11:07

本文选题：门冬氨酸钾镁　切入点：腺苷蛋氨酸　出处：《中国临床药理学杂志》2015年22期

【摘要】：目的探讨门冬氨酸钾镁和腺苷蛋氨酸在胆汁淤积性病毒性肝炎患者中的临床疗效。方法 80例胆汁淤积性病毒性肝炎患者分为对照组和试验组,各40例。试验组静脉滴注门冬氨酸钾镁30 m L,对照组静脉滴注腺苷蛋氨酸1000mg,连续治疗4周,比较2组的临床疗效,观察2组患者治疗前后的临床症状和肝功能指标改善情况。结果试验组有效率为95.0%,显著高于对照组的85.0%(P0.05)。治疗后,2组谷丙转氨酶、谷草转氨酶、总胆红素、直接胆红素、碱性磷酸酶和γ-谷氨酰转肽酶显著低于治疗前,且试验组显著低于对照组(P0.05)。试验组临床症状改善率为85.0%,显著高于对照组的57.5%(P0.05)。试验组不良反应发生率为7.5%,显著低于对照组的17.5%(P0.05)。结论门冬氨酸钾镁对胆汁淤积性病毒性肝炎的临床疗效显著,且不良反应发生率低。
[Abstract]:Objective to investigate the clinical efficacy of potassium magnesium aspartate and adenosine methionine in patients with cholestatic viral hepatitis. Methods 80 patients with cholestatic viral hepatitis were divided into control group and experimental group. 40 cases in each group were treated with potassium and magnesium aspartate 30 mL by intravenous drip, and 1 000 mg of adenosylmethionine by intravenous drip in the control group for 4 weeks. The clinical efficacy of the two groups was compared. Results the effective rate of the experimental group was 95.0, which was significantly higher than that of the control group (85.0%, P 0.05). After treatment, the two groups were treated with alanine aminotransferase, glutamic oxaloacetic transaminase, total bilirubin, direct bilirubin, total bilirubin, total bilirubin, total bilirubin, total bilirubin, total bilirubin, and total bilirubin. Alkaline phosphatase and 纬 -glutamyl transpeptidase were significantly lower than those before treatment. The improvement rate of clinical symptoms in the trial group was 85.0, which was significantly higher than that in the control group (57.5%). The incidence of adverse reactions in the trial group was 7.5%, significantly lower than that in the control group (17.5P 0.050.Conclusion potassium magnesium aspartate is effective in treating cholestasis virus. The clinical efficacy of hepatitis was remarkable. And the incidence of adverse reactions was low.
【作者单位】：奉化市中医院消化内科;浙江中医药大学第二临床医学院消化内科;
【基金】：浙江省2012年医药卫生科技计划基金资助项目(2012KYA163)
【分类号】：R512.6

【相似文献】