布加综合征患者纤维化相关细胞因子的表达

发布时间：2018-03-28 16:12

本文选题：Budd-Chiari综合征　切入点：肝硬化　出处：《中国全科医学》2015年17期

【摘要】：目的探讨纤维化相关细胞因子转化生长因子β1(TGF-β1)、血管内皮生长因子(VEGF)、缺氧诱导因子1α(HIF-1α)在布加综合征(BCS)发展至淤血性肝硬化、肝癌中的作用。方法选取2013年11月—2014年4月徐州医学院附属医院介入科收治的BCS患者47例(BCS组),肝硬化患者29例(肝硬化组),普外科患者35例(普外科组)。采集患者静脉血,并采用酶联免疫吸附法(ELISA)测定3组患者血清TGF-β1、VEGF、HIF-1α水平。结果 3组血清TGF-β1、VEGF、HIF-1α水平比较,差异均有统计学意义(P0.05);其中肝硬化组和BCS组血清TGF-β1、VEGF、HIF-1α水平均高于普外科组,BCS组血清TGF-β1水平低于肝硬化组,VEGF、HIF-1α水平高于肝硬化组(P0.05)。单纯BCS、BCS合并肝硬化、BCS合并肝癌患者血清TGF-β1、VEGF、HIF-1α水平比较,差异均有统计学意义(P0.05);其中BCS合并肝硬化、BCS合并肝癌患者血清TGF-β1、VEGF、HIF-1α水平均高于单纯BCS患者,BCS合并肝癌患者血清TGF-β1、VEGF、HIF-1α水平均高于BCS合并肝硬化患者(P0.05)。对BCS患者血清TGF-β1、VEGF、HIF-1α水平进行相关性分析,结果显示,HIF-1α与VEGF呈正相关(r=0.773,P0.05);HIF-1α与TGF-β1呈正相关(r=0.793,P0.05);TGF-β1与VEGF呈正相关(r=0.582,P0.05)。结论在单纯BCS发展至淤血性肝硬化、肝癌进程中,TGF-β1、VEGF、HIF-1α表达水平增加,早期将介入治疗和抗纤维化治疗结合,对于减少淤血性肝硬化甚至肝癌的发生至关重要。
[Abstract]:Objective to investigate the development of fibrosis related cytokines transforming growth factor 尾 1 (TGF- 尾 1), vascular endothelial growth factor (VEGF), hypoxia inducible factor 1 伪 (HIF-1 伪) to congestive cirrhosis in Budd Chiari syndrome (BCSs). Methods from November 2013 to April 2014, 47 patients with BCS in the interventional department of affiliated Hospital of Xuzhou Medical College, 29 patients with liver cirrhosis (cirrhosis group) and 35 patients with general surgery (general surgery group) were selected. The serum levels of TGF- 尾 1 and VEGFU HIF-1 伪 in three groups were determined by enzyme linked immunosorbent assay (Elisa). Results the serum levels of TGF- 尾 1 and VEGFHIF-1 伪 were compared among the three groups. The serum levels of TGF- 尾 _ 1VEGFU HIF-1 伪 in liver cirrhosis group and BCS group were higher than those in general surgery group, and the level of TGF- 尾 _ 1 HGF- 尾 _ 1 level in BCS group was lower than that in liver cirrhosis group (P 0.05). The serum levels of TGF- 尾 1 and VEGFU HIF-1 伪 in patients with BCS complicated with cirrhosis and liver cancer were higher than those in patients with BCS complicated with liver cancer. The serum levels of TGF- 尾 1 and VEGFU HIF-1 伪 in patients with BCS and liver cirrhosis were higher than those in patients with BCS complicated with liver cirrhosis (P0.05). The serum levels of TGF- 尾 1VEGFHIF-1 伪 in patients with BCS were higher than those in patients with BCS complicated with liver cirrhosis. Carrying out correlation analysis, The results showed that there was a positive correlation between HIF-1 伪 and VEGF. The expression of TGF- 尾 1 and TGF- 尾 1 were positively correlated with TGF- 尾 1. Conclusion the expression of TGF- 尾 1 and TGF- 尾 1 was positively correlated with that of VEGF. Conclusion the expression of TGF- 尾 1 VEGF HIF-1 伪 is increased in the progression of liver cancer, and early interventional therapy and anti fibrosis therapy are combined with TGF- 尾 1 to increase the expression of TGF- 尾 1 VEGF- HIF-1 伪 in the progression of liver cancer, conclusion the expression of TGF- 尾 1 and TGF- 尾 1 is significantly correlated with that of TGF- 尾 1 and TGF- 尾 1. Conclusion there is a positive correlation between HIF-1 伪 and VEGF. It is very important to reduce the occurrence of congestion cirrhosis and even liver cancer.
【作者单位】：徐州医学院公共卫生学院;
【基金】：国家自然科学基金资助项目(81172604/H2401)
【分类号】：R575.2

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