丁二磺酸腺苷蛋氨酸联合扶正化瘀胶囊治疗乙型肝炎病毒肝硬化的临床观察

发布时间：2018-04-02 05:26

本文选题：丁二磺酸腺苷蛋氨酸　切入点：扶正化淤胶囊　出处：《中国药房》2015年15期

【摘要】：目的:观察丁二磺酸腺苷蛋氨酸联合扶正化瘀胶囊治疗乙型肝炎病毒(HBV)肝硬化的临床疗效和安全性。方法:将110例HBV肝硬化患者随机均分为对照组和观察组。两组患者均接受保肝等常规治疗。在此基础上,对照组患者给予丁二磺酸腺苷蛋氨酸片500 mg,口服,bid;观察组患者在对照组治疗的基础上给予扶正化淤胶囊5粒,口服,tid。两组患者疗程均为24周。观察两组患者治疗前后肝功能指标[总胆红素(TBIL)、天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、白蛋白(ALB)]、门静脉血流动力学指标,乙型肝炎病毒脱氧核糖核酸(HBV-DNA)阴转率及不良反应发生情况。结果:观察组患者总有效率、HBV-DNA阴转率均显著高于对照组,差异均有统计学意义(P0.05)。治疗后,两组患者TBIL、AST、ALT、门静脉宽度均显著低于同组治疗前,且观察组低于对照组;ALB、门静脉流速均显著高于同组治疗前,且观察组高于对照组,差异均有统计学意义(P0.05)。两组患者治疗期间均未见明显不良反应发生。结论:丁二磺酸腺苷蛋氨酸联合扶正化瘀胶囊治疗HBV肝硬化较单用丁二磺酸腺苷蛋氨酸疗效更显著,安全性相似。
[Abstract]:Objective: to observe the clinical efficacy and safety of adenosylmethionine butylate combined with Fuzheng Huayu capsule in the treatment of hepatitis B virus (HBV) cirrhosis. Methods: 110 patients with HBV cirrhosis were randomly divided into two groups: control group and observation group. All patients in the group received routine treatment such as liver protection. On this basis, The patients in the control group were given 500 mg of adenosylmethionine butylate tablets, and the patients in the observation group were given 5 capsules of Fuzheng Huayu capsule on the basis of the treatment in the control group. The liver function indexes (total bilirubin, aspartate aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase) and portal vein hemodynamics were observed before and after treatment in both groups for 24 weeks. Results: the total effective rate of HBV-DNA in the observation group was significantly higher than that in the control group (P 0.05). The width of portal vein in both groups was significantly lower than that before treatment, and the velocity of portal vein in the observation group was significantly higher than that in the control group, and the velocity of portal vein in the observation group was higher than that in the control group, and the velocity of portal vein in the observation group was higher than that in the control group. The difference was statistically significant (P 0.05). There were no significant adverse reactions in the two groups. Conclusion: adenosylmethionine butylate combined with Fuzheng Huayu capsule is more effective than adenosine butyrate in the treatment of HBV cirrhosis. Security is similar.
【作者单位】：成都市公共卫生临床医疗中心;
【分类号】：R512.62

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